Results 131 to 140 of about 143,906 (309)

Gene expression changes in pancreatic α-cell lines following knock-out Of either CK2α or CK2α’

Biological Research
Background Protein kinase CK2 is known to exist as a tetramer of two catalytic α- or α’- subunits and two non-catalytic β-subunits, or as multimers of this tetramer.
Jens Mayer, Mandy Pack, Mathias Montenarh, Claudia Götz   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Molecular markers of insertion type in bacterias of the Moraxellaceae and Helicobacteraceae (phylum Proteobacteria) families

Medisan, 2018
A study with the use of Gupta methodology was carried out in the Biology and Geography Department of Oriente University in Santiago de Cuba, to determine molecular markers of insertion type in sequences of the DNA polimerase I proteins and DNA polimerase
Ania Margarita Cutiño Jiménez, Lianne Barrera Roca, Vivian de la Puente López, Heidy Annia Peña Cutiño   +3 more
doaj  

Crosstalk between thromboxane and bradykinin receptors in vascular smooth muscle cells - [PDF]

, 2013
Thesis (M.Sc.)-- American University of Beirut. Department of Biochemistry and Molecular Genetics. Faculty of Medicine, 2013. W 4Advisor : Dr. Ayad Jaffa, Chairman and Professor, Department of Biochemistry and Molecular Genetics ; Co-Advisor, Dr.
Dagher, Oula Khalil,
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The molecular biology and biochemistry of bacterial manganese oxidation

The molecular biology and biochemistry of bacterial manganese oxidation. This project will further the understanding of bacterial manganese (Mn2+) oxidation.

core  

Tagged library approach facilitates forward chemical genetics

, 2019
Forward chemical genetics has been highlighted as a new method for the study of various biological pathways using exogenous ligands. However, limited success in the field has demonstrated that, in many cases, it is not feasible to determine the protein ...
Kim, Yun Kyung, Chang, Young-Tae
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Psychiatric disorders are highly comorbid, heritable, and genetically correlated [1-4]. The primary objective of cross-disorder psychiatric genetics research is to identify and characterize both the shared genetic factors that contribute to convergent ...
Lee, Phil, Peyrot, Wouter J., Mallard, Travis T., Kendler, Kenneth S., Grotzinger, Andrew, Nurnberger, John I., Jr., Neale, Michael C., Edenberg, Howard J., Gandal, Michael, Mattheisen, Manuel, Andreassen, Ole A., Hettema, John M., Jonas, Katherine, Buitelaar, Jan, Cai, Na, Smoller, Jordan W., Tucker-Drob, Elliot M., Verhulst, Brad   +17 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source