Results 41 to 50 of about 1,229,349 (338)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Wanderings in Biochemistry [PDF]

Journal of Biological Chemistry, 2014
My Ph.D. thesis in the laboratory of Severo Ochoa at New York University School of Medicine in 1962 included the determination of the nucleotide compositions of codons specifying amino acids. The experiments were based on the use of random copolyribonucleotides (synthesized by polynucleotide phosphorylase) as messenger RNA in a cell-free protein ...
openaire   +3 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Carotenoids: biochemistry, pharmacology and treatment

British Journal of Pharmacology, 2016
Carotenoids and retinoids have several similar biological activities such as antioxidant properties, the inhibition of malignant tumour growth and the induction of apoptosis.
A. Milani, Marzieh Basirnejad, Sepideh Shahbazi, A. Bolhassani   +3 more
semanticscholar   +1 more source

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations [PDF]

Open Biology, 2011
Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. To date, little is known about the intrinsic catalytic properties of PINK1 since the human enzyme displays such ...
Helen I. Woodroof, Joe H. Pogson, Mike Begley, Lewis C. Cantley, Maria Deak, David G. Campbell, Daan M. F. van Aalten, Alexander J. Whitworth, Dario R. Alessi, Miratul M. K. Muqit   +9 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Age-related effects of feeder space availability on welfare of broilers reared to 56 days of age part 1: biochemical, enzymatical, and electrolyte variables

Journal of Applied Poultry Research, 2022
SUMMARY: Consumer concern about rapid growth and increased production efficiency is perceived to negatively impact the welfare of the animal. This study investigated the effects of feeder space availability on welfare of broiler chickens reared to 56 d ...
H.A. Olanrewaju, J.L. Purswell, S.D. Collier, S.L. Branton   +3 more
doaj  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The biochemistry of belief

Indian Journal of Psychiatry, 2009
Byline: T. Sathyanarayana Rao, M. Asha, K. Jagannatha Rao, P. Vasudevaraju "Man is what he believes" Anton Chekhov Beliefs are basically the guiding principles in life that provide direction and meaning in life. Beliefs are the preset, organized filters to our perceptions of the world (external and internal). Beliefs are like 'Internal commands' to the
Asha Mr, Sathyanarayana Rao Ts, Jagannatha Rao Ks, Padmaraju Vasudevaraju   +3 more
openaire   +2 more sources

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source