Results 101 to 110 of about 508,313 (310)

Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling

, 2010
Atheroma formation and restenosis following percutaneous vascular intervention involve the growth and migration of vascular smooth muscle cells (SMCs) into neointimal lesions, in part due to changes in the extracellular matrix.
Quilliam, Lawrence A., Morris, Andrew J., Leitges, Michael, Smyth, Susan S., Yang, Fanmuyi, Chrzanowska-Wodnicka, Magdalena, Panchatcharam, Manikandan, Miriyala, Sumitra, Anaya, Paul   +8 more
core   +1 more source

Cellular coordination controlling organ separation and surface integrity in plants [PDF]

, 2018
Plants are unable to relocate themselves to a more favorable location and thus have to deal with developmental programs and environmental cues wherever they happen to be.
Yuree Lee, Lee, Yuree, Kwak, June Myoung, June Myoung Kwak   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The unusual gene architecture of polyubiquitin is created by dual-specific splice sites

Genome Biology
Background The removal of introns occurs through the splicing of a 5′ splice site (5′ss) with a 3′ splice site (3′ss). These two elements are recognized by distinct components of the spliceosome. However, introns in higher eukaryotes contain many matches
Chaorui Duan, Truman Mooney, Luke Buerer, Cory Bowers, Stephen Rong, Seong Won Kim, Alger M. Fredericks, Sean F. Monaghan, William G. Fairbrother   +8 more
doaj   +1 more source

Conformational Dynamics and Cleavage Sites of Cas12a Are Modulated by Complementarity between crRNA and DNA

iScience, 2019
Summary: Cas12a is an RNA-guided endonuclease, which displays great potentials and several advantages over the well-known Cas9 in genome editing and engineering.
Lujia Zhang, Ruirui Sun, Mengyi Yang, Sijia Peng, Yongxin Cheng, Chunlai Chen   +5 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor

iScience, 2019
Summary: Subtilase cytotoxin (SubAB) is a virulence factor produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains.
Toshiyuki Yamaji, Hisatoshi Hanamatsu, Tsuyoshi Sekizuka, Makoto Kuroda, Norimasa Iwasaki, Makoto Ohnishi, Jun-ichi Furukawa, Kinnosuke Yahiro, Kentaro Hanada   +8 more
doaj   +1 more source

Chromatin supraorganization, DNA fragmentation, and cell death in snake erythrocytes

, 2015
In nucleate erythrocytes of several vertebrate groups, the frequency and intensity of DNA fragmentation associated with programed cell death vary considerably.
Miyamoto, M, Vidal, BC, Mello, MLS, Vidal, Benedicto C, Miyamoto, Maristela, Mello, Maria Luiza S   +5 more
core   +1 more source

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure [PDF]

, 2007
The Golgi apparatus consists of a series of flattened cisternal membranes that are aligned in parallel to form stacks. Cytosolic-oriented Golgi-associated proteins have been identified that may coordinate or maintain the Golgi architecture.
van der Goot, G., Orschot, V., Viola Oorschot, Klumperman, J., van Eijk, M., Dora Kaloyanova, J. Bernd Helms, Li, X. Y., Felix T. Wieland, Gisou van der Goot, Friedrich Lottspeich, Li, X., Martin van Eijk, Vytaute Starkuviene, Kaloyanova, D., Eerland, R., Ruud Eerland, Helms, J. B., Xueyi Li, Starkuviene, V., Judith Klumperman, Oorschot, V., Lottspeich, F., Wieland, F. T.   +23 more
core   +1 more source