Results 101 to 110 of about 538,242 (306)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry [PDF]

, 2010
BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an evolutionarily conserved adaptor between microtubule motors and their cargo that was previously shown to link vesicles and mRNP complexes to the dynein motor.
Tanenbaum Marvin E., Daniël Splinter, Tanenbaum, M.E. (Marvin), Akhmanova Anna, Marvin E Tanenbaum, Frauke Melchior, René H Medema, Tanenbaum, Marvin E., Fornerod Maarten, Fornerod, M, Tanenbaum, ME, Lindqvist, A. (Arne), Medema René H., Grigoriev, I, Melchior, Frauke, Flotho, A, Grigoriev Ilya, Jaarsma, D. (Dick), Melchior, F, Hoogenraad Casper C., Jaarsma Dick, Flotho, Annette, Arne Lindqvist, Splinter Daniël, Flotho Annette, Yu Ka Lou, Hoogenraad, CC, Demmers Jeroen, Keijzer, N. (Nanda), Medema, R.H. (Rene), Keijzer, Nanda, Splinter, D. (Daniël), Splinter, EC, Lindqvist Arne, Melchior Frauke, Maarten Fornerod, Fornerod, Maarten, Yu, Ka Lou (Carol), Nanda Keijzer, Haasdijk, Elize, Lindqvist, Arne, Engelsma, D, Demmers, Jeroen, Akhmanova, A.S. (Anna), Engelsma Dieuwke, Fornerod, M.W.J. (Maarten), Annette Flotho, Haasdijk Elize D., Jaarsma, Dick, Yu, Carol, Elize D Haasdijk, Flotho, A. (Annette), Haasdijk, E.D. (Elize), Hoogenraad, C.C. (Casper), Anna Akhmanova, Medema, René H., Grigoriev, I. (Ilya), Jeroen Demmers, Yu, K.L., Engelsma, Dieuwke, Engelsma, D. (Dieuwke), Dick Jaarsma, Ilya Grigoriev, Splinter, Daniel, Hoogenraad, Casper C., Casper C Hoogenraad, Dieuwke Engelsma, Lindqvist, A, Melchior, F. (Frauke), Grigoriev, Ilya, Keijzer Nanda, Medema, RH, Akhmanova, Anna, Ka Lou Yu, Demmers, J.A.A. (Jeroen)   +74 more
core   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Phospholipase D1 regulates cell migration in a lipase activity-independent manner

, 2006
Cell migration, a complex biological process, requires dynamic cytoskeletal remodeling. Phospholipase D (PLD) generates phosphatidic acid, a lipid second messenger. Although PLD activity has been proposed to play a role in cytoskeletal rearrangement, the
Kim, JH, Pann-Ghill Suh, Kim, HW, Hyeona Jeon, Ryu, SH, Jung Hwan Kim, Suh, Pann-Ghill, Suh, PG, Sung Ho Ryu, Jeon, H, Hyun-wook Kim   +10 more
core   +1 more source

The silicon trypanosome [PDF]

, 2010
African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
Bakker, BM, Barrett, M.P., Michael P. Barrett, Westerhoff, Hans V., Breitling, Rainer, Westerhoff, HV, Breitling, R., Bakker, Barbara M.; id_orcid, Girolami, M, Girolami, Mark, Breitling, R, Michels, Paul A. M., Girolami, M., Paul A. M. Michels, Barbara M. Bakker, Barrett, Michael P., Bakker, B.M., Westerhoff, H.V.; id_orcid, Krauth-Siegel, R.L., Bakker, Barbara M., Michels, PAM, R. Luise Krauth-siegel, Clayton, C, Matthews, K, Clayton, C., Keith Matthews, Bakker, B., Matthews, Keith; id_orcid, Clayton, Christine, Christine Clayton, Rainer Breitling, Krauth-Siegel, R. Luise, Mark Girolami, Michels, Paulus, Hans V. Westerhoff, ,, Matthews, K., Michels, P.A.M., Westerhoff, H.V., Barrett, MP, Westerhoff, Hans V.; id_orcid, Michels, Paul A M, Krauth-Siegel, RL, Matthews, Keith   +43 more
core   +2 more sources

The unusual gene architecture of polyubiquitin is created by dual-specific splice sites

Genome Biology
Background The removal of introns occurs through the splicing of a 5′ splice site (5′ss) with a 3′ splice site (3′ss). These two elements are recognized by distinct components of the spliceosome. However, introns in higher eukaryotes contain many matches
Chaorui Duan, Truman Mooney, Luke Buerer, Cory Bowers, Stephen Rong, Seong Won Kim, Alger M. Fredericks, Sean F. Monaghan, William G. Fairbrother   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Metabolomic systems biology of trypanosomes [PDF]

, 2010
Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
Barrett, M.P., Michael P. Barrett, Breitling, Rainer, Breitling, R., Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Rainer Breitling, Barbara M. Bakker, Barrett, Michael P., Bakker, Barbara M.,, Bakker, B.M., Barrett, Michael P.,, Bakker, Barbara M.   +12 more
core   +2 more sources