Results 91 to 100 of about 538,242 (306)

Agrobacterium virulence factors induce the expression of host DNA repair-related genes without promoting major genomic damage

Scientific Reports
This study aimed to investigate whether the plant DNA damage levels and DNA damage response (DDR) are regulated during Agrobacterium infection and potentially manipulated by Agrobacterium to facilitate T-DNA integration. We investigated the plant genomic
Benoît Lacroix, Anna Fratta, Hagit Hak, Yufei Hu, Vitaly Citovsky   +4 more
doaj   +1 more source

Sensing and Degradation of Organophosphorus Compounds by Exploitation of Heat-Loving Enzymes

Chemosensors
The increasing incidence of organophosphate (OP) pesticide poisoning and the use of OP chemical warfare agents (CWA) in conflicts and terrorist acts need sustainable methods for sensing, decontamination, and detoxification of OP compounds.
Giuseppe Manco, Eros A. Lampitella, Nagendra S. K. Achanta, Giuliana Catara, Maria Marone, Elena Porzio   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Logic-Based Models for the Analysis of Cell Signaling Networks [PDF]

, 2010
Computational models are increasingly used to analyze the operation of complex biochemical networks, including those involved in cell signaling networks. Here we review recent advances in applying logic-based modeling to mammalian cell biology.
Julio Saez-rodriguez, Sorger, Peter K., Morris, Melody K., Melody K. Morris, Sorger, Peter, Morris, Melody Kay, Lauffenburger, Douglas A., Peter K. Sorger, Saez-Rodriguez, Julio, Douglas A. Lauffenburger   +9 more
core   +1 more source

Hematopoietic stem/progenitor cell transplantation recovers immune defects and prevents lymphomas in Atm-deficient mice

Experimental Hematology & Oncology
Background Ataxia-telangiectasia (A-T) is a rare autosomal recessive multi-system and life-shortening disease, characterized by progressive cerebellar neurodegeneration, immunodeficiency, radiation sensitivity and cancer predisposition, with high ...
Bruna Sabino Pinho de Oliveira, Alessandro Giovinazzo, Sabrina Putti, Matilde Merolle, Tiziana Orsini, Giuseppe D. Tocchini-Valentini, Christophe Lancrin, Fabio Naro, Manuela Pellegrini   +8 more
doaj   +1 more source

Neonatal Pig Sertoli Cells Survive Xenotransplantation by Creating an Immune Modulatory Environment Involving CD4 and CD8 Regulatory T Cells

Cell Transplantation, 2020
The acute cell-mediated immune response presents a significant barrier to xenotransplantation. Immune-privileged Sertoli cells (SC) can prolong the survival of co-transplanted cells including xenogeneic islets, hepatocytes, and neurons by protecting them
Gurvinder Kaur, Kandis Wright, Payal Mital, Taylor Hibler, Jonathan M. Miranda, Lea Ann Thompson, Katelyn Halley, Jannette M. Dufour   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Strategic Optimization of Nanoparticle Characteristics to Enhance Tumor Targeting and Doxorubicin Delivery

International Journal of Nanomedicine
Young-Jin Lee, Jisan Hong, Bo-Yeon Seo, Byung-Heon Lee, Vijaya Sarangthem,* Rang-Woon Park* Department of Biochemistry and Cell Biology, Cell & Matrix Research Institute, Kyungpook National University, School of Medicine, Daegu, 41944,
Lee YJ, Hong J, Seo BY, Lee BH, Sarangthem V, Park RW   +5 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Systems biology in animal sciences [PDF]

, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Pas, M.F.W., te, M.A. Smits, Veerkamp, R.F., Woelders, H., Bannink, A., M.F.W. Te Pas, Pas, M., R.F. Veerkamp, Smits, M.A., H. Woelders, A. Bannink, te Pas, M.F.W.   +11 more
core   +1 more source