Results 71 to 80 of about 538,242 (306)

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important.
Barton, Geoffrey J, Peter J Coote, Botting, Catherine H., Katherine A Gould, Geoffrey J Barton, Hinds, Jason, Overton, Ian M., Gould, Katherine A., Coote, Peter J, Gould, Katherine A, Shirran, Sally, Botting, CH, Catherine H Botting, Barton, GJ, Coote, Peter J., Gould, KA, Shirley Graham, Botting, Catherine H, Overton, IM, Ian M Overton, Overton, Ian M, Barton, Geoffrey J., Graham, Shirley, Shirran, S, Overton, Ian M; id_orcid, Hinds, J, Sally Shirran, Coote, PJ, Jason Hinds, Barton, Geoffrey J.; id_orcid, Graham, S   +30 more
core   +1 more source

G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome

iScience, 2019
Summary: DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes.
Nitu Kumari, Supriya V. Vartak, Sumedha Dahal, Susmita Kumari, Sagar S. Desai, Vidya Gopalakrishnan, Bibha Choudhary, Sathees C. Raghavan   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Mechanosensitive Hair Cell-Like Cells from Embryonic and Induced Pluripotent Stem Cells

, 2018
Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance. The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for the permanence of hearing loss and certain balance disorders.
Peng, AW, Diensthuber, M, Heller, S, Ricci, AJ, Oshima, K, Shin, K   +5 more
core   +1 more source

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression [PDF]

, 2008
Embryonic stem (ES) cell self-renewal is regulated by transcription factors, including Oct4, Sox2, and Nanog. A number of additional transcriptional regulators of ES cell self-renewal have recently been identified, including the orphan nuclear receptor ...
Yates, A. (Adam), Takacs, K. (Katalin), Chambers, Ian, van den Berg, Debbie, Berg, D.L.C. (Debbie) van den, Takacs, K, Engelen, Erik, Yates, Adam, Demmers, Jeroen, Zhang, Wensheng, Poot, Raymond, Takacs, Katalin, Engelen, M.P. (Erik), Bezstarosti, K. (Karel), Poor, R.A. (Raymond), Zhang, WS, Yates, A, van den Berg, Debbie L. C., Chambers, I. (Ian), Engelen, E, Zhang, W. (Wensheng), Poot, Raymond A., Chambers, I, Bezstarosti, Karel, Demmers, J.A.A. (Jeroen)   +24 more
core   +1 more source

Inhibitors of sterol synthesis. Effects of a new fluorinated analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one in rats.

Journal of Lipid Research, 1994
3 beta-Hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one (VII), an analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one (I) in which conversion to 26- and 25-oxygenated metabolites is blocked by the F7-substitution, was ...
N Gerst, F D Pinkerton, A Kisic, W K Wilson, S Swaminathan, G.J. Schroepfer, Jr.   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Rapid, low-cost detection of Zika virus using programmable biomolecular components

, 2018
The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions.
Dudley, Dawn M., Daringer, Nicole M., Green, Alexander A., Lee, Jeong Wook, Fan, Melina, O'Connor, David H., Ferrante, Tom, Lambert, Guillaume, Pardee, Keith, Braff, Dana, Takahashi, Melissa K., Ma, Duo, Bosch, Irene, Donghia, Nina, Gehrke, Lee, Collins, James J.   +15 more
core   +1 more source

Phosphotyrosine proteomics reveals novel Zap70 and Itk pathway targets downstream of TCR and CAR in Jurkat T cells

Scientific Reports
Ζ-associated protein of 70 kDa (Zap70) and interleukin-2-inducible T cell kinase (Itk) propagate the primary and CD28-integrated phosphotyrosine (pY) signalling, respectively, to achieve full T cell activation.
Aurora Callahan, Savannah S. Trychanh, Timothy Ro, Aisharja Mojumdar, Arthur R. Salomon   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source