Results 61 to 70 of about 508,313 (310)

CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis

, 2015
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the endoplasmic reticulum and activation of the Unfolded Protein Response (UPR).
Stevens, James L., Willy, Jeffrey A., Young, Sara K., Masuoka, Howard C., Wek, Ronald C.   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Timing and cell specificity of senescence drives postnatal lung development and injury

Nature Communications, 2023
Senescence causes age-related diseases and stress-related injury, but it is also physiologically essential during development. Here, Yao et al. show that programmed senescence in mesenchymal cells orchestrates postnatal lung development and that neonatal
Hongwei Yao, Joselynn Wallace, Abigail L. Peterson, Alejandro Scaffa, Salu Rizal, Katy Hegarty, Hajime Maeda, Jason L. Chang, Nathalie Oulhen, Jill A. Kreiling, Kelsey E. Huntington, Monique E. De Paepe, Guilherme Barbosa, Phyllis A. Dennery   +13 more
doaj   +1 more source

Small molecule-based disruption of the Axin/beta-catenin protein complex regulates mesenchymal stem cell differentiation

, 2018
The Wnt/beta-catenin pathway plays important roles in the differentiation of multiple cell types, including mesenchymal stem cells. Using a cell-based chemical screening assay with a synthetic chemical library of 270 000 compounds, we identified the ...
Kim, H, Kim, DE, Cho, JW, Park, HS, Han, JK, Bae, SJ, Park, SH, Ha, NC, Choi, SR, Gwak, J, Hwang, SG, Oh, S   +11 more
core   +1 more source

Assessing what prospective laboratory assistants in biochemistry and cell biology know: development and validation of the test instrument PROKLAS [PDF]

, 2016
Background: Laboratory assistants in biology and medicine play a central role in the operation of laboratories in hospitals, research institutes, and industries.
JĂśrg Großschedl (3762451), Ute Harms (3762445), Chakraverty, Devasmita, Gantner, Stefan, Großschedl, Jörg, Devasmita Chakraverty (1536061), Gantner, Stephan, Stephan Gantner (3762442), Harms, Ute   +8 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Inhibitors of sterol synthesis. Effects of a new fluorinated analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one in rats.

Journal of Lipid Research, 1994
3 beta-Hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one (VII), an analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one (I) in which conversion to 26- and 25-oxygenated metabolites is blocked by the F7-substitution, was ...
N Gerst, F D Pinkerton, A Kisic, W K Wilson, S Swaminathan, G.J. Schroepfer, Jr.   +5 more
doaj   +1 more source

Keeping the Vimentin Network Under Control: Cell-matrix Adhesion-associated Plectin 1f Affects Cell Shape and Polarity of Fibroblasts

, 2010
Monitoring Editor: M. Bishr Omary Focal adhesions (FAs) located at the ends of actin/myosin-containing contractile stress fibers form tight connections between fibroblasts and their underlying extracellular matrix.
Lilli Winter, Gerald Burgstaller, Wiche, Gerhard (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Gerhard Wiche, Martin Gregor, Winter, Lilli (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Gregor, Martin (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Burgstaller, Gerald (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna)   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Phosphotyrosine proteomics reveals novel Zap70 and Itk pathway targets downstream of TCR and CAR in Jurkat T cells

Scientific Reports
Ζ-associated protein of 70 kDa (Zap70) and interleukin-2-inducible T cell kinase (Itk) propagate the primary and CD28-integrated phosphotyrosine (pY) signalling, respectively, to achieve full T cell activation.
Aurora Callahan, Savannah S. Trychanh, Timothy Ro, Aisharja Mojumdar, Arthur R. Salomon   +4 more
doaj   +1 more source