Results 41 to 50 of about 538,242 (306)
Mathematical modelling of cancer invasion : implications of cell adhesion variability for tumour infiltrative growth patterns [PDF]
, 2014 Cancer invasion, recognised as one of the hallmarks of cancer, is a complex, multiscale phenomenon involving many inter-related genetic, biochemical, cellular and tissue processes at different spatial and temporal scales.
Trucu, Dumitru; id_orcid +4 more
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Integrated quantitative phosphoproteomics and cell-based functional screening reveals specific pathological cardiac hypertrophy-related phosphorylation sites [PDF]
, 2021 ©The Korean Society for Molecular and Cellular Biology.Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation.
Park, Sung-Gyoo +10 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Cancer immunotherapy with T-cell targeting cytokines: IL-2 and IL-7
, 2021 Clinical trials have demonstrated that an increased number of effector cells, especially tumor-specific T cells, is positively linked with patients' prognosis. Although the discovery of checkpoint inhibitors (CPIs) has led to encouraging progress in
Seung-Woo Lee, 김지혜, 이건주
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Towards molecular systems biology of gene transcription and regulation [PDF]
, 2010 Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
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Biochemistry Research InternationalThis study investigates the phytochemical composition and biological activities of Heliotropium indicum and Caesalpinia bonduc, two medicinal plants widely used in traditional medicine in Benin. In ethnomedicinal practice, H. indicum is commonly prepared
Funkè F. Assouma +12 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2013 Surface plasmon resonance (SPR) is a powerful technique for monitoring the affinity and selectivity of biomolecular interactions. SPR allows for analysis of association and dissociation rate constants and modeling of biomolecular interaction kinetics, as
Stahelin, Robert V.
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BORIS/CTCFL is an RNA-binding protein that associates with polysomes [PDF]
, 2013 © 2013 Ogunkolade et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution ...
Silver, AR +10 more
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