Results 51 to 60 of about 538,242 (306)

From input to impact: embedding PPI in computational ovarian cancer research

Research Involvement and Engagement
Public and Patient Involvement (PPI) is increasingly recognised as a valuable component of health research, yet there are no published examples of its implementation in computational biology.
Aideen McCabe, Bridget Carr, Catherine Hogan, Christine Campbell, Deirdre Healy, Krista Costello, Maeve O’Donnell, Paula Carroll, Abha Gupta, Kellie Dean   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Cell Migration with Multiple Pseudopodia: Temporal and Spatial Sensing Models [PDF]

, 2013
Cell migration triggered by pseudopodia (or “false feet”) is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon.
ALLENA, Rachele
core   +1 more source

Study of the cell biology and biochemistry of cherubism. [PDF]

Journal of Clinical Pathology, 1998
AIMS: To establish whether the multinucleate cells in lesions of patients with cherubism are also osteoclasts and if this is the case whether they were responsive to calcitonin; to carry out cytogenetic studies on two members of the same family affected by cherubism in an attempt to identify any major chromosomal defects; and to perform an in-depth ...
J, Southgate, U, Sarma, J V, Townend, J, Barron, A M, Flanagan   +4 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells [PDF]

, 2013
SummaryDefining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity.
Soga, Tomoyoshi, Ikeda, Eiji, Rahimi, Yasmeen, Nagamatsu, G, Ikeda, E, Kobayashi, Hiroshi, Goda, N, Johnson, RS, Nakamura-Ishizu, Ayako, Suda, Toshio, Takubo, Keiyo, Soga, T, Nakamura-Ishizu, A, Nagamatsu, Go, Goda, Nobuhito, Takubo, K, 池田, 栄二, Kobayashi, CI, Hirao, Atsushi, Kobayashi, H, Rahimi, Y, Suematsu, Makoto, Kobayashi, Chiharu I., Johnson, Randall S.   +23 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Portable, on-demand biomolecular manufacturing

, 2019
Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs, therapeutic proteins, and other commodities. However, the need for specialized equipment and refrigeration for production and distribution poses a challenge for the
Lewandowski, Michael, Slomovic, Shimyn, Lee, Jeong Wook, Burrill, Devin, Ferrante, Tom, Vernet, Andyna, Joshi, Neel S., Pardee, Keith, McSorley, Fern R., Yoshikazu Furuta, Donghia, Nina, Collins, James J., Nguyen, Peter Q., Boddy, Christopher N.   +13 more
core   +1 more source

Correction to: Comparing Serum Zinc and Cortisol Concentrations in Patients with Major Depressive Disorder Treated with Fluoxetine and Cognitive-Behavioral Therapy: A Randomized Clinical Trial [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Mehrdad Jalalian1, Mehdi Pourasghar2, Ahmad Majd3, Hossein Ghalehnoei4, Zahra Kianmehr5 1 PhD Student in Biochemistry, Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran 2 Associate
Mehrdad Jalalian, Mehdi Pourasghar, Ahmad Majd, Hossein Ghalehnoei, Zahra Kianmehr   +4 more
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source