Results 21 to 30 of about 497,856 (261)

Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection

Molecular Systems Biology, 2010
Systems biology can offer a great deal of insight into evolution by quantitatively linking complex properties such as protein structure, folding, and function to the fitness of an organism.
Matthew I Peña, Milya Davlieva, Matthew R Bennett, John S Olson, Yousif Shamoo   +4 more
doaj   +1 more source

Role of Retinoic Acid Receptor-γ in DNA Damage-Induced Necroptosis

iScience, 2019
Summary: DNA-damaging compounds, commonly used as chemotherapeutic drugs, are known to trigger cells to undergo programmed cell death such as apoptosis and necroptosis.
Chamila Kadigamuwa, Swati Choksi, Qing Xu, Christophe Cataisson, Steven S. Greenbaum, Stuart H. Yuspa, Zheng-gang Liu   +6 more
doaj   +1 more source

Zebrafish Larvae Position Tracker (Z-LaP Tracker): a high-throughput deep-learning behavioral approach for the identification of calcineurin pathway-modulating drugs using zebrafish larvae

Scientific Reports, 2023
Brain function studies greatly depend on quantification and analysis of behavior. While behavior can be imaged efficiently, the quantification of specific aspects of behavior is labor-intensive and may introduce individual biases. Recent advances in deep
Sayali V. Gore, Rohit Kakodkar, Thaís Del Rosario Hernández, Sara Tucker Edmister, Robbert Creton   +4 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phytochemical Profile and Biological Activities of the Roots of Caesalpinia bonduc and the Aerial Part of Heliotropium indicum

Biochemistry Research International
This study investigates the phytochemical composition and biological activities of Heliotropium indicum and Caesalpinia bonduc, two medicinal plants widely used in traditional medicine in Benin. In ethnomedicinal practice, H. indicum is commonly prepared
Funkè F. Assouma, Durand Dah-Nouvlessounon, Atchadé Pascal Tchogou, Machioud Maxime Sangaré, Gautier Roko, Bawa Boya, Yao Paul Attien, Olaréwadjou Amogou, Rachidatou Kamirou, Basile Konmy, Adolphe Adjanohoun, Lamine Baba-Moussa, Haziz Sina   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

From input to impact: embedding PPI in computational ovarian cancer research

Research Involvement and Engagement
Public and Patient Involvement (PPI) is increasingly recognised as a valuable component of health research, yet there are no published examples of its implementation in computational biology.
Aideen McCabe, Bridget Carr, Catherine Hogan, Christine Campbell, Deirdre Healy, Krista Costello, Maeve O’Donnell, Paula Carroll, Abha Gupta, Kellie Dean   +9 more
doaj   +1 more source