Results 21 to 30 of about 538,242 (306)

Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice

Scientific Reports, 2022
miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard.
Dillon Shapiro, Ryan Massopust, Thomas Taetzsch, Gregorio Valdez   +3 more
doaj   +1 more source

Biochemistry and cell biology of silica formation in sponges [PDF]

Microscopy Research and Technique, 2003
AbstractThe main inorganic material forming the skeletal elements in Demospongiae as well as in Hexactinellida, the spicules, is amorphous silica. The spicules occur in the cytoplasm and the extracellular space and also in the nucleus (as silicate crystals) of some sponge cells; the function in the latter compartment is unknown.
Werner E G, Müller, Anatoli, Krasko, Gaël, Le Pennec, Heinz C, Schröder   +3 more
openaire   +2 more sources

Forty Years of FEBS 1964 to 2003 [PDF]

, 2004
Memoir for the 40th Anniversary of the Federation of European Societies for Biochemistry and Molecular Biology ...
Feldmann, Horst
core   +1 more source

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion [PDF]

, 2011
MRCK alpha and MRCK beta (myotonic dystrophy kinase-related Cdc42-binding kinases) belong to a subfamily of Rho GTPase activated serine/threonine kinases within the AGC-family that regulate the actomyosin cytoskeleton.
Ewald Schroder, Pang Leon, Diane Crighton, Schroder Ewald, Kaye Sarah J., Turnbull Andrew, Olson, M.F., Michael F Olson, Heikkila, T., Olson Michael F., Sarah J. Kaye, Mezna Mokdad, Timo Heikkila, Rushbrooke Mathew, Wheatley, E., Alexandra Boakes, Turnbull, A., Mokdad Mezna, Rushbrooke, M., Crighton, D., Kaye, S.J., Schroder, E., Leon Pang, Boakes, A., Mezna, M., Pang, L., Heikkila Timo, Crighton Diane, Edward Wheatley, Wheatley Edward, Mathew Rushbrooke, Andrew Turnbull, Sarah J Kaye, Boakes Alexandra, Michael F. Olson   +34 more
core   +2 more sources

So what do we really mean when we say that systems biology is holistic? [PDF]

, 2010
Background: An old debate has undergone a resurgence in systems biology: that of reductionism versus holism. At least 35 articles in the systems biology literature since 2003 have touched on this issue.
Gatherer, Derek
core   +5 more sources

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

Nature Communications, 2016
The Piwi-interacting RNA (piRNA) pathway is known to suppress transposable elements in gonadal tissues. Here the authors provide evidence for a functional piRNA pathway in the somatic cells of theDrosophilafat body with roles in metabolism, immunological
Brian C. Jones, Jason G. Wood, Chengyi Chang, Austin D. Tam, Michael J. Franklin, Emily R. Siegel, Stephen L. Helfand   +6 more
doaj   +1 more source

The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

Nature Communications, 2023
The MUC2 mucin is a large, highly glycosylated polymer that builds the intestinal mucus. Here, the authors generate a high-resolution structural model of the 800 amino acid C-terminal dimer including its glycans.
Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V. Recktenwald, Malin E. V. Johansson, Gunnar C. Hansson   +5 more
doaj   +1 more source

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis [PDF]

, 2013
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the integrated stress response (ISR)
McClintick, Jeanette N., Shan, Jixiu, Fusakio, Michael E., Kilberg, Michael S., Wek, Ronald C., Zhou, Donghui, Teske, Brian F.   +6 more
core   +1 more source

Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury

Respiratory Research, 2022
Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating evidence supports the vascular hypothesis of BPD, in which lung endothelial cell dysfunction drives this ...
Jason L. Chang, Jiannan Gong, Salu Rizal, Abigail L. Peterson, Julia Chang, Chenrui Yao, Phyllis A. Dennery, Hongwei Yao   +7 more
doaj   +1 more source

Corrigendum to “Effects of therapeutic hypothermia on the gut microbiota and metabolome of infants suffering hypoxic-ischemic encephalopathy at birth” [Int. J. Biochem. Cell Biol. 93 (December) (2017), 110-118] [PDF]

, 2019
peer-reviewedCorrigendum Refers to: Watkins, C., Murphy, K., Yen, S., Carafa, I., Dempsey, E., O’Shea, C., Vercoe, E., Ross, R., Stanton, C. and Ryan, C. (2017).
Ryan, Cornelius A., O’ Shea, C. A., Watkins, Claire, STANTON, CATHERINE, Murphy, Kevin M., Yen, Sandi, Carafa, Ilaria, Ross, R Paul, Dempsey, Eugene M., Allen-Vercoe, Emma   +9 more
core   +1 more source