Results 11 to 20 of about 497,757 (162)
Peptides as multifunctional players in cancer therapy
Experimental and Molecular Medicine, 2023 Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have
Sri Murugan Poongkavithai Vadevoo +7 more
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Scientific Reports, 2022 miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard.
Dillon Shapiro +3 more
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Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging
Molecular & Cellular Oncology, 2018 Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar +5 more
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MedEdPORTAL, 2009 This is a problem-based learning case for a medical biochemistry-molecular biology course suitable for first- or second-year medical students. The case is that of a young girl who is diagnosed as a compound heterozygote for Gaucher disease and is treated
Marshall Anderson
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Scientific Reports, 2023 More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence after initial treatment, highlighting our incomplete understanding of how chemoresistant populations evolve over the course of EOC progression post chemotherapy ...
Carolina Mejia Peña +5 more
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Biochemistry and cell biology of silica formation in sponges [PDF]
Microscopy Research and Technique, 2003 AbstractThe main inorganic material forming the skeletal elements in Demospongiae as well as in Hexactinellida, the spicules, is amorphous silica. The spicules occur in the cytoplasm and the extracellular space and also in the nucleus (as silicate crystals) of some sponge cells; the function in the latter compartment is unknown.
Werner E G, Müller +3 more
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Nature Communications, 2023 The MUC2 mucin is a large, highly glycosylated polymer that builds the intestinal mucus. Here, the authors generate a high-resolution structural model of the 800 amino acid C-terminal dimer including its glycans.
Pablo Gallego +5 more
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A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
Nature Communications, 2016 The Piwi-interacting RNA (piRNA) pathway is known to suppress transposable elements in gonadal tissues. Here the authors provide evidence for a functional piRNA pathway in the somatic cells of theDrosophilafat body with roles in metabolism, immunological
Brian C. Jones +6 more
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Respiratory Research, 2022 Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating evidence supports the vascular hypothesis of BPD, in which lung endothelial cell dysfunction drives this ...
Jason L. Chang +7 more
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Detection of Extracellular Vesicle RNA Using Molecular Beacons
iScience, 2020 Summary: Extracellular vesicles (EVs) have recently emerged as intercellular conveyors of biological information and disease biomarkers. Identification and characterization of RNA species in single EVs are currently challenging.
Getulio Pereira de Oliveira, Jr. +9 more
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