Results 11 to 20 of about 18,159 (171)
Increased intervals in enzyme replacement therapy for stable type 1 Gaucher disease: A non-inferiority sequential trial emulation. [PDF]
Abstract Objective To compare the efficacy and safety of extended interval (Q3–4W) enzyme replacement therapy (ERT) versus standard biweekly (Q2W) ERT in clinically stable type 1 Gaucher disease (GD) patients. Methods We emulated a target trial with a sequential trial design, using data from the French Gaucher Disease Registry.
Beydon M +31 more
europepmc +2 more sources
Lifelong Evolution of Autoreactive Plasma Cell Numbers, Affinity, and Anatomic Location in Arthritic K/BxN Mice. [PDF]
Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Vanhoucke T +8 more
europepmc +2 more sources
ACTA1-Related Adult-Onset Scapuloperoneal Myopathy With Cores and Rods. [PDF]
We report a patient with an adult‐onset, slowly progressive, ACTA1‐related scapuloperoneal myopathy with cores and rods, determined by the heterozygous variant NM_001100.4:c.1001C > T, p.(Pro334Leu). The scapuloperoneal phenotype could represent a distinct subcategory, and the characterisation of this patient with a less severe, different clinical ...
Caramizaru A +10 more
europepmc +2 more sources
Changements hématologique et biochimique dans la trypanosomose humaine et animale
Les trypanosomoses se caractérisent, en général, par de l’anémie, de la leucopénie, de la thrombocytopénie, ainsi que par des troubles du métabolisme d’où résultent de l’hypoglycémie, une élévation du taux d’azote uréique du sang, de l’hypoalbuminémie ...
V.O. Anosa
doaj +1 more source
Toxicity, Antibacterial, and Phytochemical Analyses of Antrocaryon klaineanum Pierre Extracts
Medicinal plants are traditionally used in Gabon to treat several types of illnesses. The study’s purpose was to determine the toxic, antibacterial, and anti-inflammatory effects of Antrocaryon klaineanum Pierre extracts and to characterize their ...
Cédric Sima Obiang +9 more
doaj +1 more source
Depuis le début de l’année 1987, l’élevage du cerf rusa (Cervus timorensis russa) se développe en Nouvelle-Calédonie. En 1988, au cours d’une opération d’abattage en élevage, l’auteur a réalisé près de 90 prélèvements de sang pour définir les constantes
Laurent Audigé
doaj +1 more source
Les biomarqueurs en écotoxicologie : définition, intérêt, limite, usage [PDF]
Les biomarqueurs sont des outils mis en oeuvre pour établir un diagnostic de risque environnemental. Leurs usages et leur intérêt, notamment dans la détermination du risque de pollution, sont devenus incontournables surtout depuis que la directive cadre ...
J. GARRIC, S. MORIN, F. VINCENT-HUBERT
doaj +2 more sources
Efficacy and safety of once-weekly insulins in type 2 diabetes: A systematic review and meta-analysis. [PDF]
Abstract Aims Once‐weekly (OW) insulins represent a promising strategy to reduce injection burden and improve adherence in type 2 diabetes management. This meta‐analysis aimed to quantify pooled effect sizes for key biological and clinical outcomes, integrating new findings from the five large trials published in 2025.
Bourron O, Denimal D.
europepmc +2 more sources
A brief account of the developments in biochemistry at the Faculty of Science of the University of Geneva is given from its emergence from organic chemistry at the Ancienne Ecole de chimie to today's Department of Biochemistry at the Section de ...
Jacques Deshusses, Howard Riezman
doaj +1 more source
La révolution moléculaire en biologie comprend quatre volets : l’identification chimique du matériel héréditaire en tant qu’acide nucléique polymérisé, l’élucidation des structures des macromolécules biologiques, la preuve que la structure et la biosynthèse des protéines – en particulier des enzymes – sont gouvernées par des gènes spécifiques ; plus ...
+7 more sources

