Results 31 to 40 of about 18,159 (171)

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

Genetic Predisposition to Diabetic Nephropathy: Role of I/D ACE Gene Polymorphism

Journal de la Faculté de Médecine d'Oran, 2020
Introduction - Diabetic nephropathy is the leading cause of chronic kidney disease and the most common and serious complication of diabetes. Its exact pathogenesis is complex and not completely elucidated.
Sabah HANACHI , Karima SIFI , Khalida BOUDAOUD, Salima ZEKRI, Sara HOUCHE , Hanane HOUAMEL, Soumia HASSINI, karima BENEMBAREK, Nouredine ABADI   +8 more
doaj   +2 more sources

Unlocking the Functionalization and Reactivity of Ethylene Bridges in [2.2]Paracyclophanes: Strategies and Challenges

European Journal of Organic Chemistry, EarlyView.
Bridging the gap. Beyond deck functionalization, the ethylene bridges of [2.2]paracyclophanes offer a largely unexploited reactivity landscape. This review showcases strategies to functionalize these bridges and leverage them to build novel cyclophane architectures.
Rongyu Sun, Tamara Ye, Laurent Micouin, Erica Benedetti   +3 more
wiley   +1 more source

First‐Trimester Down Syndrome Screening in Renal‐Transplanted Pregnant Women: Blood Creatinine Levels Impact False‐Positive Rate

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Over the past few decades, several thousand pregnancies following kidney transplantation have been monitored but few studies have reported on first‐trimester Down syndrome screening. This study aimed to assess the performance of such screening and its relationship with renal function.
Clément Burgy, Lisa Chanourdie, Béatrice Guyard‐Boileau, Anne‐Laure Hebral, Annelise Genoux, Marie‐Sophie Combis, Paul Guerby, Christophe Vayssiere, Safouane M. Hamdi   +8 more
wiley   +1 more source

Données récentes touchant à la nutrition et appliquées à l'alimentation animale

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1955
Aucun résumé disponible.
R. Ferrando
doaj   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

In vitro analytical interference of L-ascorbic acid in enzymatic assays based on the Trinder reaction [PDF]

Batna Journal of Medical Sciences
Introduction: Ascorbic acid, a water-soluble compound with antioxidant properties, can interfere with several enzymatic methods used in clinical biochemistry.
Mohamed Abdou OUDRER, Oussama FERHAT, Ikram TERBECHE, Mustapha ZENDJABIL, Amel Soulef SAADI- OUSLIM   +4 more
doaj   +1 more source

Microbial Controls on Dissolved Organic Nitrogen Cycling During Long‐Term Degradation Experiments

Geophysical Research Letters, Volume 53, Issue 10, 28 May 2026.
Abstract Dissolved organic nitrogen (DON) is critical for marine microbial growth by providing carbon and nitrogen. Although DON is rapidly cycled, some compounds within this pool can persist for long‐periods of time. To better understand how DON is cycled by marine microorganisms, we conducted 548‐day incubations using surface‐derived dissolved ...
Richard LaBrie, Roxane Maranger, Luc Tremblay, Jennifer Cherrier, Jean‐Eric Tremblay, Nagissa Mahmoudi   +5 more
wiley   +1 more source

High-yield production of human Dicer by transfection of human HEK293-EBNA1 cells grown in suspension

BMC Biotechnology, 2018
Background Dicer is a 219-kDa protein that plays key roles in gene regulation, particularly as the ribonuclease III enzyme responsible for cleaving precursor miRNA substrates.
Jonathan Bouvette, Dursun Nizam Korkut, Aurélien Fouillen, Soumiya Amellah, Antonio Nanci, Yves Durocher, James G. Omichinski, Pascale Legault   +7 more
doaj   +1 more source

MAVISp: A modular structure‐based framework for protein variant effects

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and ...
Matteo Arnaudi, Mattia Utichi, Kristine Degn, Matteo Tiberti, Ludovica Beltrame, Karolina Krzesińska, Pablo Sánchez‐Izquierdo Besora, Eleni Kiachaki, Simone Scrima, Laura Bauer, Katrine Meldgård, Anna Melidi, Lorenzo Favaro, Anu Oswal, Guglielmo Tedeschi, Terézia Dorčaková, Alberte Heering Estad, Joachim Breitenstein, Jordan Safer, Paraskevi Saridaki, Valentina Sora, Francesca Maselli, Philipp Becker, Jérémy Vinhas, Alberto Pettenella, Matteo Lambrughi, Claudia Cava, Anna Rohlin, Mef Nilbert, Sumaiya Iqbal, Peter Wad Sackett, Burcu Aykac Fas, Elena Papaleo   +32 more
wiley   +1 more source