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Development and Recent Advances in Lysine and N-Terminal Bioconjugation for Peptides and Proteins
Molecules, 2023 The demand for creation of protein diversity and regulation of protein function through native protein modification and post-translational modification has ignited the development of selective chemical modification methods for peptides and proteins ...
Ajcharapan Tantipanjaporn, Man-Kin Wong
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Photoredox C–H functionalization leads the site-selective phenylalanine bioconjugation
Scientific Reports, 2022 Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine ...
Yue Weng +3 more
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Polypeptide–polymer bioconjugates [PDF]
Chem. Soc. Rev., 2010 Creating bioconjugates by combining polymers with peptides and proteins is an emerging multidisciplinary field of research that has enjoyed increased attention within the scientific community. This critical review provides an overview of the strategies employed for the construction of these materials and will highlight the underlying synthetic methods ...
Canalle, L.A. +2 more
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Nanomaterials, 2021 Antibody–nanoparticle conjugates are widely used analytical reagents. An informative parameter reflecting the conjugates’ properties is the number of antibodies per nanoparticle that retain their antigen-binding ability.
Dmitriy V. Sotnikov +3 more
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Serine-Selective Bioconjugation
Journal of the American Chemical Society, 2020 The first general method for the rapid, chemoselective, and modular functionalization of serine residues in native polypeptides is reported. Using a reagent platform based on P(V) oxidation state, this redox-economic approach can be used to append nearly any kind of cargo onto serine generating a stable, benign, and hydrophilic phosphorothioate linkage.
Vantourout, Julien C +16 more
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Frontiers in Chemistry, 2022 Hydrogel biomaterials in combination with living cells are applied in cell biology, tissue engineering and regenerative medicine. In particular, poly(acrylamide) (PAM) hydrogels are frequently used in cell biology laboratories as soft substrates for 2D ...
Alexis Wolfel +2 more
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Advances in Bioconjugation [PDF]
Current Organic Chemistry, 2010 Bioconjugation is a burgeoning field of research. Novel methods for the mild and site-specific derivatization of proteins, DNA, RNA, and carbohydrates have been developed for applications such as ligand discovery, disease diagnosis, and high-throughput screening.
Jeet, Kalia, Ronald T, Raines
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Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
Molecules, 2020 In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility ...
Bethany Almeida +3 more
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Current Targets and Bioconjugation Strategies in Photodynamic Diagnosis and Therapy of Cancer
Molecules, 2020 Photodynamic diagnosis (PDD) and therapy (PDT) are emerging, non/minimally invasive techniques for cancer diagnosis and treatment. Both techniques require a photosensitizer and light to visualize or destroy cancer cells.
Salvador Gomez, Allan Tsung, Zhiwei Hu
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Molecules, 2022 This study reports the therapeutic effectiveness of doxorubicin-conjugated zinc oxide nanoparticles against lung cancer cell line. The zinc oxide nanoparticles (ZnONPs) were first synthesised using a fungus, isolated from air with an extraordinary ...
Prakriti Mishra +7 more
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