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Fast Cysteine Bioconjugation Chemistry
Chemistry – A European Journal, 2022AbstractCysteine bioconjugation serves as a powerful tool in biological research and has been widely used for chemical modification of proteins, constructing antibody‐drug conjugates, and enabling cell imaging studies. Cysteine conjugation reactions with fast kinetics and exquisite selectivity have been under heavy pursuit as they would allow clean ...
Fa‐Jie Chen, Jianmin Gao
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Nickel-Catalyzed Antibody Bioconjugation
Journal of the American Chemical Society, 2023New biocompatible methods for post-translational protein modification are challenging to develop but crucial to create improved chemical probes and optimize next-generation biologic therapies such as antibody-drug conjugates (ADCs). Herein, we describe the bottom-up construction of an aqueous nickel-catalyzed cross-coupling for the chemospecific ...
Vlad Bacauanu +3 more
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Metal-free bioconjugation reactions
Drug Discovery Today: Technologies, 2013The recent strategy to apply chemical reactions to address fundamental biological questions has led to the emergence of entirely new conjugation reactions that are fast and irreversible, yet so mild and selective that they can be performed even in living cells or organisms.
Berkel, S.S. van, Delft, F.L. van
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Collagen-Like Peptide Bioconjugates
Bioconjugate Chemistry, 2017Collagen-like peptides (CLPs), also known as collagen-mimetic peptides (CMPs), are short synthetic peptides that mimic the triple helical conformation of native collagens. Traditionally, CLPs have been widely used in deciphering the chemical basis for collagen triple helix stabilization, mimicking collagen fibril formation and fabricating other higher ...
Tianzhi Luo, Kristi L. Kiick
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Polymer Chemistry, 2011
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Hest, J.C.M. van, Sumerlin, B.
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Hest, J.C.M. van, Sumerlin, B.
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