Results 31 to 40 of about 9,219 (186)

Bioconjugation Strategies for Microtoroidal Optical Resonators

Sensors, 2010
The development of label-free biosensors with high sensitivity and specificity is of significant interest for medical diagnostics and environmental monitoring, where rapid and real-time detection of antigens, bacteria, viruses, etc., is necessary ...
Heather K. Hunt, Carol Soteropulos, Andrea M. Armani   +2 more
doaj   +1 more source

Modular Assembly of Dynamic Polymer Networks From Heteroaffinity Cross‐Links to Multivalent Proteins

Angewandte Chemie, EarlyView.
This study develops a method to modularly assemble oligomeric binding proteins, like streptavidin, using heterobifunctional cross‐linkers that have both a strong‐ and a weak‐affinity binding moiety. These dynamic cross‐linkers enable the assembly of polymer networks with unique meta‐stable nonequilibrium topologies, and that exhibit chemically tunable ...
Tianyue Dai, Yuntao Qiu, Katherine M. Leon Hernandez, Wesley Chan, Katrina Mejia, Natalia Nemeria, Colin D. Kinz‐Thompson   +6 more
wiley   +2 more sources

Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo

Molecules, 2019
N-Alkylation and N-acylation of the prostaglandin-F2α allosteric modulator l-PDC31 were performed to install various alkyl, PEG and isoprenoid groups onto the l-enantiomer of the peptide.
Julien Poupart, Xin Hou, Sylvain Chemtob, William D. Lubell   +3 more
doaj   +1 more source

An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag Short title: Controlled bioconjugation via O-glycan engineering

mAbs, 2021
Bioconjugates are an important class of therapeutic molecules. To date, O-glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous O-glycosylation pathway and the lack of an O-glycosylation ...
Thomas V. Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Emmanuel Rossy, Alessandra Rossi, Sivaneswary Genapathy, Giulia Tamburrino, Nicola Rath, Natalie Tigue, Vivian Lindo, Tristan Vaughan, Monika A. Papworth   +13 more
doaj   +1 more source

Bioinspired Stabilization of Fluorescent Au@SiO2 Tracers for Multimodal Biological Imaging

Advanced Functional Materials, EarlyView.
This study demonstrates a bioinspired stabilization strategy for fluorescent gold‐silica nanoparticles. Inspired by natural biosilica maturation, high‐temperature calcination transforms the silica shells, preventing dissolution in cell culture media and intracellular environments.
Wang Sik Lee, Henry Lee, Patricia Taladriz‐Blanco, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +5 more
wiley   +1 more source

Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury

Drug Delivery, 2017
The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety.
Nan Li, Dong Weng, Shan-Mei Wang, Yuan Zhang, Shan-Shan Chen, Zhao-Fang Yin, Jiali Zhai, Judy Scoble, Charlotte C. Williams, Tao Chen, Hui Qiu, Qin Wu, Meng-Meng Zhao, Li-Qin Lu, Xavier Mulet, Hui-Ping Li   +15 more
doaj   +1 more source

Development of a novel glycoengineering platform for the rapid production of conjugate vaccines

Microbial Cell Factories, 2023
Conjugate vaccines produced either by chemical or biologically conjugation have been demonstrated to be safe and efficacious in protection against several deadly bacterial diseases.
Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Bossé, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren, Jon Cuccui   +15 more
doaj   +1 more source

Nanobiosensor Based on Catalytic Palladium Nanoclusters and Oxidases for Bianalyte Electrochemical Determination: Glucose and Ethanol in Sweat

Advanced Healthcare Materials, EarlyView.
A nanobiosensor for fast and simultaneous determination of sweat glucose and ethanol is presented. Deposited oxidase enzymes consume oxygen in the presence of the substrates, and co‐deposited palladium nanoclusters catalyze the electrochemical oxygen reduction, basis of the detection.
Alejandro Rodríguez‐Penedo, Estefanía Costa‐Rama, Beatriz Fernández, M. Teresa Fernández‐Abedul   +3 more
wiley   +1 more source

Toward Optimized ⁸⁹Zr-Immuno-PET: Side-by-Side Comparison of [⁸⁹Zr]Zr-DFO-, [⁸⁹Zr]Zr-3,4,3-(LI-1,2-HOPO)- and [⁸⁹Zr]Zr-DFO*-Cetuximab for Tumor Imaging: Which Chelator Is the Most Suitable?

Pharmaceutics, 2022
89Zr represents a highly favorable positron emitter for application in immuno-PET (Positron Emission Tomography) imaging. Clinically, the 89Zr4+ ion is introduced into antibodies by complexation with desferrioxamine B.
Helen Damerow, Xia Cheng, Valeska von Kiedrowski, Ralf Schirrmacher, Björn Wängler, Gert Fricker, Carmen Wängler   +6 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source