Results 41 to 50 of about 9,219 (186)

Bioconjugation as a promising method for vaccine development

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Bioconjugation, or protein glycan coupling technology, PGCT, is a method for creating carbohydrate-protein composites based on the ability of certain bacteria to perform eukaryotic-type glycosylation.
Maria I. Tsyganova, Dmitry V. Novikov, Viktor V. Novikov, Alexander V. Karaulov   +3 more
doaj   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts

Nature Communications
Late-stage specific and selective diversifications of peptides and proteins performed at target residues under ambient conditions are recognized to be the most facile route to various and abundant conjugates.
Guangjun Bao, Xinyi Song, Yiping Li, Zeyuan He, Quan Zuo, Ruiyao E, Tingli Yu, Kai Li, Junqiu Xie, Wangsheng Sun, Rui Wang   +10 more
doaj   +1 more source

Organic–Inorganic Hybrid Nanomaterials

Nanomaterials, 2019
The paramount progress in the field of organic−inorganic hybrid nanomaterials was stimulated by numerous applications in chemistry, physics, life sciences, medicine, and technology.
Valentine P. Ananikov
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Exploring Protein Bioconjugation: A Redox-Based Strategy for Tryptophan Targeting

Research
Amino acid bioconjugation technology has emerged as a pivotal tool for linking small-molecule fragments with proteins, antibodies, and even cells. The study in Nature by Chang and Toste introduces a redox-based strategy for tryptophan bioconjugation ...
Qian-Qian Yang, Shuai-Jiang Liu, Wei Huang, Cheng Peng, Bo Han   +4 more
doaj   +1 more source

Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Nature Communications
Proteins labelled site-specifically with small molecules are valuable assets for chemical biology and drug development. The unique reactivity profile of the 1,2-aminothiol moiety of N-terminal cysteines (N-Cys) of proteins renders it highly attractive ...
Mudassir H. Mir, Sangeeta Parmar, Chhaya Singh, Dimpy Kalia   +3 more
doaj   +1 more source

Synthesis and Applications of Porphyrin-Biomacromolecule Conjugates

Frontiers in Chemistry, 2021
With potential applications in materials and especially in light-responsive biomedicine that targets cancer tissue selectively, much research has focused on developing covalent conjugation techniques to tether porphyrinoid units to various ...
Pravin Pathak, Mohammad Amin Zarandi, Xiao Zhou, Janarthanan Jayawickramarajah, Janarthanan Jayawickramarajah   +4 more
doaj   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases. [PDF]

Angew Chem Int Ed Engl
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Poulou E, Ruwolt M, Stieger CE, Kemnitz-Hassanin K, Hackenberger CPR.   +4 more
europepmc   +2 more sources

Antibody Conjugates: From Heterogeneous Populations to Defined Reagents

Antibodies, 2015
Monoclonal antibodies (mAbs) and their derivatives are currently the fastest growing class of therapeutics. Even if naked antibodies have proven their value as successful biopharmaceuticals, they suffer from some limitations.
Patrick Dennler, Eliane Fischer, Roger Schibli   +2 more
doaj   +1 more source