Results 91 to 100 of about 67,723 (299)
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias.
Alleman, Rick J. +1 more
core
Dominant optic atrophy caused by a novel OPA1 mutation: Disruption of the mitochondrial network with preserved bioenergetics. [PDF]
The aim of this study was to determine the pathogenetic mechanism of autosomal dominant optic atrophy (ADOA). Bioenergetic failure, abnormalities of the mitochondrial network and increased susceptibility to apoptosis have all been proposed as possible ...
SOLAINI G +18 more
core +1 more source
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang +13 more
wiley +1 more source
Prediction of bioenergetics components of lepidopterous larva [PDF]
Using the bioenergetics data for the final instar Achaea Janata larva exposed to a wide range of ration levels and temperatures, a linear regression model to predict the bioenergetics components of lepidopterous larva has been developed.
Pandian, T. J., Muthukrishnan, J.
core +1 more source
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang +5 more
wiley +1 more source
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu +12 more
wiley +1 more source
DIET, CIRCULATING FACTORS, AND EXOSOMES MEDIATE NEURONAL AND SYSTEMIC BIOENERGETICS
Alzheimer’s disease currently affects an estimated 6.5 million people in the US, but the underlying mechanisms that trigger pathology remain unclear and available therapies do not stop disease progression.
Amick, Kimberly Allison
core +1 more source
The indiscriminate discharge and leakage of waste motor oil (WMO), enriched with heavy metals, polycyclic aromatic hydrocarbons (PAHs), and other persistent organic contaminants, constitute a major and persistent source of environmental pollution ...
Komal Sharma, Dipti Agarwal, Vineet Soni
doaj +1 more source

