Results 81 to 90 of about 67,723 (299)

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes [PDF]

, 2020
Background Mitochondrial transplantation has been recently explored for treatment of very ill cardiac patients. However, little is known about the intracellular consequences of mitochondrial transplantation.
Pour, Paria Ali, Kenney, M Cristina, Kheradvar, Arash   +2 more
core   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Chlorophyll a fluorescence kinetics of mung bean (Vigna radiata L.) grown under artificial continuous light

Biochemistry and Biophysics Reports, 2020
Continuous light can be used as a tool to understand the diurnal rhythm of plants and it can also be used to increase the plant production. In the present research, we aimed to investigate the photosynthetic performance of V.
Deepak Kumar, Hanwant Singh, Shani Raj, Vineet Soni   +3 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Role Of Trypanosoma Cruzi Peroxiredoxins In Mitochondrial Bioenergetics

, 2015
Trypanosoma cruzi cytosolic (TcCPx) and mitochondrial tryparedoxin peroxidase (TcMPx) play a fundamental role in H 2O 2 detoxification. Herein, mitochondrial bioenergetics was evaluated in cells that overexpressed TcCPx (CPx) and TcMPx (MPx) and in pTEX.
Pineyro M.D., Ribeiro L.H.G., Robello C., Gadelha F.R., Vitor S.C., De Figueiredo Peloso E.   +5 more
core   +1 more source

Cellular bioenergetics.

, 2022
Effect of intermittent glucose (G only)/glucose+fructose (G+0.1F, G+1F) exposure on cellular bioenergetics, described by (A) basal OCR, (B) complex V OCR, (C) maximal respiration, (D) proton leak, (E) NMOCR and (F) ECAR. Data are shown as mean ±SD for n =
David P. Macfarlane (12542743), Andrew T. Treweeke (12542740), Maria Luisa Fiorello (12542737), Ian L. Megson (493664)   +3 more
core   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Reactive oxygen species as integrators of stress signalling and developmental regulation in plants

Discover Plants
Reactive oxygen species (ROS) serve as both critical signalling molecules and potent cytotoxins. Generated predominantly in chloroplasts, mitochondria, peroxisomes, and the apoplast, ROS arise as by-products of aerobic metabolism and are further induced ...
Aditi Mishra, Anjali Bhardwaj, Upma Bhatt, Vineet Soni   +3 more
doaj   +1 more source

Assessment of waterlogging-induced changes in enzymatic antioxidants and carbohydrate metabolism in peanuts genotypes

Biochemistry and Biophysics Reports
Soil flooding, manifesting as submergence or waterlogging stress, significantly impacts plant species composition and agricultural productivity, particularly in regions with low rainfall.
Shubhangani Sharma, Upma Bhatt, Garishma shah, Vineet Soni   +3 more
doaj   +1 more source