Results 81 to 90 of about 102,774 (287)

Current research in biotechnology: Exploring the biotech forefront [PDF]

open access: yes, 2019
Biotechnology is an evolving research field that covers a broad range of topics. Here we aimed to evaluate the latest research literature, to identify prominent research themes, major contributors in terms of institutions, countries/regions, and journals.
Silva A. S.   +110 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Frontiers in Bioengineering and Biotechnology

open access: yes
Frontiers in Bioengineering and Biotechnology publishes articles across a wide research spectrum. The mission of the journal is to bring all relevant bioengineering and biotechnology areas together on a single ...
cristofolini luca
core   +1 more source

Protocol for rolling circle amplification-based nanopore sequencing of eccDNA from cell and plasma samples

open access: yesSTAR Protocols
Summary: Extrachromosomal circular DNAs (eccDNAs) can drive copy number variation and genomic rearrangements and act as mobile regulators of gene expression. Here, we detail a protocol for eccDNA identification from cell and plasma samples.
Biyuan Miao   +8 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Protocol for whole-tissue immunolabeling, optical clearing, and lightsheet imaging of c-Fos protein expression in unsectioned mouse brains

open access: yesSTAR Protocols
Summary: The c-Fos protein has been broadly utilized as a marker of neuronal activity, and conventional immunohistochemistry to determine its expression relies on tissue sections.
Koukou Fu, Jing Yang
doaj   +1 more source

Advances in Bioengineering [PDF]

open access: yes, 2015
The technological approach and the high level of innovation make bioengineering extremely dynamic and this forces researchers to continuous updating. It involves the publication of the results of the latest scientific research.

core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

Protocol to express anti-viral nanobodies and antigenic proteins anchored on the bacterial cell surface through the engineering of probiotic Escherichia coli Nissle 1917

open access: yesSTAR Protocols
Summary: Here, we present a protocol to express anti-viral nanobodies or antigenic proteins anchored on the bacterial cell surface through the engineering of probiotic E. coli Nissle 1917 (EcN).
Nitin S. Kamble   +4 more
doaj   +1 more source

Environmental Biotechnology [PDF]

open access: yes, 2013
Taking into consideration the outstanding importance of studying and applying the biological means to remove or mitigate the harmful effects of global pollution on the natural environment, as direct consequences of quantitative expansion and qualitative ...

core   +1 more source

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