Results 21 to 30 of about 9,371 (163)

Predictive Potential of C_max Bioequivalence in Pilot Bioavailability/Bioequivalence Studies, through the Alternative ƒ₂ Similarity Factor Method

Pharmaceutics, 2023
Pilot bioavailability/bioequivalence (BA/BE) studies are downsized trials that can be conducted prior to the definitive pivotal trial. In these trials, 12 to 18 subjects are usually enrolled, although, in principle, a sample size is not formally ...
Sara Carolina Henriques, Paulo Paixão, Luis Almeida, Nuno Elvas Silva   +3 more
doaj   +1 more source

Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood–brain barrier permeability

Journal of Nanobiotechnology
The blood–brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS).
Suyi Liu, Xingyue Jin, Yuanyuan Ge, Junlin Dong, Xinyue Liu, Xiao Pei, Ping Wang, Bing Wang, Yanxu Chang, Xie-an Yu   +9 more
doaj   +1 more source

MicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy

Frontiers in Pharmacology
Diabetic cardiomyopathy (DCM) is a prominent contributor to morbidity and mortality in people with diabetes worldwide. In diabetic patients, it is a chronic condition that is characterized by ventricular hypertrophy (VH), diastolic dysfunction ...
Akash De, Arnab Sarkar, Tanmoy Banerjee, Rudranil Bhowmik, Shuvam Sar, Md. Adil Shaharyar, Sanmoy Karmakar, Nilanjan Ghosh   +7 more
doaj   +1 more source

Pharmacokinetic and bioequivalence study of Telzap® in comparison with Mikardis® in healthy subjects after single administrationl

Фармакокинетика и Фармакодинамика, 2023
Introduction. Telmisartan is widely used in clinical practice during hypertension treatment. It is a specific angiotensin II receptor antagonist (type AT1), effective at oral intake, A bioequivalence study of Telzap® and Mikardis® was conducted with 60 ...
A. L. Khokhlov, A. A. Khokhlov, A. E. Miroshnikov, O. V. Lebedeva, D. Yu. Grebenkin   +4 more
doaj   +1 more source

Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology
Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases.
Haifan Liu, Xingyue Jin, Suyi Liu, Xinyue Liu, Xiao Pei, Kunhui Sun, Meifang Li, Ping Wang, Yanxu Chang, Tiejie Wang, Bing Wang, Xie-an Yu   +11 more
doaj   +1 more source

Elaboration of technology and comparative research of pellets of tamsulosin the modified liberation

Бюллетень сибирской медицины, 2011
The work purpose consisted in elaboration of technology of reception pellets of tamsulosin with the modified liberation, and also an estimation of their comparative bioequivalence with a comparison preparation.
Ye. V. Blynskaya, N. A. Uvarov, Ye. Ye. Lazareva, V. K. Alexeyev   +3 more
doaj   +1 more source

Generative Neural Networks for Addressing the Bioequivalence of Highly Variable Drugs

Algorithms
Bioequivalence assessment of highly variable drugs (HVDs) remains a significant challenge, as the application of scaled approaches requires replicate designs, complex statistical analyses, and varies between regulatory authorities (e.g., FDA and EMA ...
Anastasios Nikolopoulos, Vangelis D. Karalis   +1 more
doaj   +1 more source

Generic drugs: myths, facts, and limitations

Italian Journal of Medicine, 2012
Bioequivalence (BE) has always been an important pharmaceutical area, particularly (but not solely) in Mediterranean region, where the use of generic drugs is a relatively recent development. The lack of new therapeutic molecules has concentrated primary
Antonio Marzo, Elisabetta Porro, Anna Barassi   +2 more
doaj   +1 more source

Influence of Different Populations on Pharmacokinetic Bioequivalence Results: Can We Extrapolate Bioequivalence Results from One Population to Another?

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Purpose: Over the last 15 years, an ever-increasing proportion of pharmacokinetic bioequivalence studies for European/North American generic submissions appeared to have been conducted in geographical/ethnic populations other than those for which the ...
Deniz Ozdin, Murray P. Ducharme, France Varin, Anders Fuglsang, Dina Al-Numani   +4 more
doaj   +1 more source

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Pharmacology Research & Perspectives, 2021
The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned.
Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo   +6 more
doaj   +1 more source