Immunomodulatory role of vasoactive intestinal peptide and ghrelin in Oncorhynchus mykiss [PDF]
Heliyon, 2023 Neuropeptides are a group of peptides derived from precursor proteins synthesized in neuronal and nonneuronal cells. The classical functions of neuropeptides have been extensively studied in mammals, including neuromodulation in the central nervous ...
Carolina Muñoz-Flores +13 more
doaj +2 more sources
Co-Formulation of Recombinant Porcine IL-18 Enhances the Onset of Immune Response in a New Lawsonia intracellularis Vaccine [PDF]
Vaccines, 2023 Pig is one of the most consumed meats worldwide. One of the main conditions for pig production is Porcine Enteropathy caused by Lawsonia intracellularis.
Angela Hidalgo-Gajardo +13 more
doaj +2 more sources
First report of bovine viral diarrhea virus subgenotypes 1d and 1e in southern Chile [PDF]
Virology Journal, 2023 Bovine viral diarrhea virus (BVDV) affects cattle worldwide causing severe productive and economic loss. In this study, we investigated the subgenotypes of BVDV circulating in cattle samples from the Aysén region, an active cattle breeding area located ...
Florence Hugues +12 more
doaj +2 more sources
Chronic Cholestatic Liver Disease Induced by Larval Ascariasis: Novel Insights Into Immune-Mediated Pathogenesis and Hepatic Fibrosis in Mice. [PDF]
FASEB JLiver alterations induced by single infection (SI) or reinfection (RE) with 250 or 2500 Ascaris suum eggs in mice. Histological analysis shows inflammatory cell infiltration (eosinophils, lymphocytes, macrophages, and neutrophils), fibrotic areas, and bile duct proliferation in infected animals compared with uninfected controls.
Souza JLN +16 more
europepmc +2 more sources
Development of New Potential Inhibitors of β1 Integrins through In Silico Methods—Screening and Computational Validation [PDF]
Life, 2022 Integrins are transmembrane receptors that play a critical role in many biological processes which can be therapeutically modulated using integrin blockers, such as peptidomimetic ligands.
Disraeli Vasconcelos +8 more
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Genomic Insights Into Respiratory Syncytial Virus Circulation Patterns and Neutralization by Anti-F Monoclonal Antibodies in Panama (2018-2024). [PDF]
Influenza Other Respir VirusesABSTRACT Background Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections and hospitalization in infants and children. Whole genome sequencing (WGS) plays a critical role in understanding the evolution and epidemiology of RSV.
Franco D +24 more
europepmc +2 more sources
Safety and immunogenicity of a SARS-CoV-2 Gamma variant RBD-based protein adjuvanted vaccine used as booster in healthy adults [PDF]
Nature Communications, 2023 A Gamma Variant RBD-based aluminum hydroxide adjuvanted vaccine called ARVAC CG was selected for a first in human clinical trial. Healthy male and female participants (18-55 years old) with a complete COVID-19-primary vaccine scheme were assigned to ...
Karina A. Pasquevich +24 more
doaj +2 more sources
Assessment of a porcine circovirus type 2 vaccine prototype through anatomopathological analysis and its correlation with blood viral load [PDF]
Frontiers in Veterinary SciencePorcine circovirus type 2 (PCV2) is an endemic pathogen of global relevance, responsible for porcine circovirus-associated diseases (PCVAD). Consequently, vaccination against PCV2 is a standard practice in intensive swine production systems.
Fernanda Larenas-Muñoz +7 more
doaj +2 more sources
New insight into the biological activity of Salmo salar NK-lysin antimicrobial peptides [PDF]
Frontiers in ImmunologyNK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like proteins family first isolated from a pig’s small intestine.
Leonardo Ortega +22 more
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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection [PDF]
Nature CommunicationsIn the context of continuous emergence of SARS-CoV-2 variants of concern (VOCs), one strategy to prevent the severe outcomes of COVID-19 is developing safe and effective broad-spectrum vaccines.
Lorena M. Coria +33 more
doaj +2 more sources