Results 11 to 20 of about 1,385 (152)

Treatment with a Zinc Metalloprotease Purified from Bothrops moojeni Snake Venom (BmooMP-Alpha-I) Reduces the Inflammation in an Experimental Model of Dextran Sulfate Sodium-Induced Colitis. [PDF]

Mediators Inflamm, 2019
It has been described that the metalloprotease BmooMP‐alpha‐I purified from Bothrops moojeni snake venom is able to hydrolyze the TNF molecule. However, this observation has been based mainly on in vitro investigation, in addition to molecular modeling and docking approaches.
Silva MC, Sales-Campos H, Oliveira CJF, Silva TL, França FBF, Oliveira F, Mineo TWP, Mineo JR.   +7 more
europepmc   +2 more sources

The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer

Molecular Oncology, Volume 16, Issue 4, Page 904-920, February 2022., 2022
Our study investigates the molecular effects elicited by the vitamin D derivative calcitriol in patients with breast cancer (BC). We showed that ERRα deregulated calcitriol/VDR‐dependent transcription, causing estrogen pathway activation and upregulation of the calcitriol degradation enzyme CYP24A1.
Katia Danza, Letizia Porcelli, Simona De Summa, Roberta Di Fonte, Brunella Pilato, Rosanna Lacalamita, Simona Serratì, Amalia Azzariti, Stefania Tommasi   +8 more
wiley   +1 more source

A New Platelet-Aggregation-Inhibiting Factor Isolated from Bothrops moojeni Snake Venom. [PDF]

Biomed Res Int, 2017
This work reports the purification and functional characterization of BmooPAi, a platelet‐aggregation‐inhibiting factor from Bothrops moojeni snake venom. The toxin was purified by a combination of three chromatographic steps (ion‐exchange on DEAE‐Sephacel, molecular exclusion on Sephadex G‐75, and affinity chromatography on HiTrap™ Heparin HP ...
de Sousa BB, Mamede CCN, Matias MS, Pereira DFDC, de Queiroz MR, Dias EHV, Silva ACA, Dantas NO, Costa JO, de Oliveira F.   +9 more
europepmc   +2 more sources

Absence of a significant pharmacokinetic interaction between atorvastatin and fenofibrate: A randomized, crossover, study of a fixed-dose formulation in healthy Mexican subjects

Frontiers in Pharmacology, 2015
Several clinical trials have substantiated the efficacy of the co-administration of statins like atorvastatin and fibrates. Without information currently available about the interaction between the two drugs, a pharmacokinetic study was conducted to ...
Omar ePatiño-Rodríguez, Rosa María eMartínez-Medina, Irma eTorres-Roque, Maricela eMartínez-Delgado, America Susana Mares-Garcia, Abraham eEscobedo-Moratilla, Amador eCovarrubias-Pinedo, Angélica eArzola-Paniagua, José Luis eHerrera-Torres, José ePérez-Urizar   +9 more
doaj   +1 more source

Redes de consejo en la industria biotecnológica en Francia [PDF]

, 2010
En este artículo exploramos las redes de consejo inter-organizacionales, apoyándonos en la idea de que la naturaleza de las interdependencias funcionales entre los actores es diferente a nivel intra-organizacional y a nivel interorganizacional.
Lazega, Emmanuel, Piña, Álvaro
core   +8 more sources

Qualidade de cápsulas de sibutramina manipuladas em três farmácias de Belo Horizonte, MG, Brasil [PDF]

Infarma: Pharmaceutical Sciences, 2015
A sibutramina é um anorexígeno indicada como fármaco de primeira escolha para o tratamento da obesidade. Devido a inexistência de monografia farmacopeica para análise e controle de qualidade deste fármaco e que a sibutramina apresenta classificação ...
Grazielle Heloiza SANGUINETE, Isaias de Paula CAMPOS NETO, Ivanete Aparecida Rodrigues GONÇALVES ; Maria Betânia de Freitas MARQUES   +2 more
doaj   +1 more source

Modelo de evaluación de la gestión organizacional del ciclo I+D+I en empresa biofarmacéutica de alta tecnología (MEGO-EBAT): caso Centro de Inmunología Molecular

Revista Cubana de Administración Pública y Empresarial, 2023
Los modelos de gestión de la innovación en el sector tradicional son diferentes a los de la alta tecnología, y en el sector biofarmacéutico se reportan estudios fragmentados del ciclo cerrado de I+D+i que no dan respuesta al tránsito de una entidad de ...
Mayra Mercedes Espinosa Valdés, Mercedes Delgado Fernández, Agustín Lage Dávila   +2 more
doaj   +1 more source

In vitro dissolution profile of primaquine tablets available for malaria treatment in Brazil [PDF]

, 2008
A ineficácia clínica de muitos medicamentos tem servido de alerta para estudos mais profundos sobre os componentes da formulação, processos empregados e características físico-químicas dos fármacos.
FERRAZ, Humberto Gomes, RODRIGUES, Letícia Norma Carpentieri, WATANABE, Sayuri Pereira   +2 more
core   +2 more sources

Los sistemas vegetales como plataformas de producción de proteínas de interés para la industria farmacéutica

Dominguezia, 2020
La biotecnología vegetal logró armonizar los nuevos desarrollos relacionados con los sistemas productivos vegetales con la necesidad de proteínas recombinantes de la industria farmacéutica.
María Alejandra Alvarez
doaj   +2 more sources

Old World camels in a modern world – a balancing act between conservation and genetic improvement

Animal Genetics, Volume 50, Issue 6, Page 598-612, December 2019., 2019
Summary Old World camels have served humans in cross‐continental caravans, transporting people and goods, connecting different cultures and providing milk, meat, wool and draught since their domestication around 3000–6000 years ago. In a world of modern transport and fast connectivity, these beasts of burden seem to be out‐dated.
P. A. Burger, E. Ciani, B. Faye
wiley   +1 more source