Results 221 to 230 of about 449,966 (339)

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Exosome profile and composite indices reflect immune exhaustion in periodontitis. [PDF]

Sci Rep
Bonilla M, Bravo M, Peñalver I, Mesa F.
europepmc   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Autonomous biogenesis of all thirty proteins of the Escherichia coli translation machinery. [PDF]

Nat Commun
Schwarz-Schilling M, Cohen I, Dupin A, Avidan N, Barak Y, Shimizu Y, Daube SS, Bar-Ziv RH.   +7 more
europepmc   +1 more source

Biogenesis of the Mitochondrial TOM Complex [PDF]

, 2007
Thomas Becker, Sylvia Pfannschmidt, Bernard Guiard, Diana Stojanovski, Dusanka Milenkovic, Stephan Kutik, Nikolaus Pfanner, Chris Meisinger, Nils Wiedemann   +8 more
openalex   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

γ-Elemene Impairs Mitochondrial Biogenesis in Breast Cancer Cells by Upregulating GCN5-Mediated PGC-1α Acetylation. [PDF]

Biomol Ther (Seoul)
Tang L, Wang M, Liu J, Yu Q, Chen C, Jia L, Xia J.   +6 more
europepmc   +1 more source

Biogenesis and regulatory hierarchy of phased small interfering RNAs in plants [PDF]

, 2018
Pingchuan Deng, Sajid Muhammad, Min Cao, Liang Wu   +3 more
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Zinc pyrithione impairs iron-sulfur cluster biogenesis in Mycobacterium tuberculosis. [PDF]

BMC Microbiol
Wang L, Wang X, Xu L, Wang B, Ji D, Ye Y, Lu Y.   +6 more
europepmc   +1 more source