Results 251 to 260 of about 439,213 (293)

A 3,4-diamino-substituted coumarin derivative as a TRBP inhibitor suppresses tumor growth in breast cancer by inducing cellular senescence. [PDF]

Am J Cancer Res
Zhao D, Peng T, He Q, Ruan S, Xie J, Zhao Y, Qin L, Zhang B, Liu X, He Y.   +9 more
europepmc   +1 more source

Engineering Metal‐Organic‐Framework‐Based STING Nanoagonists for PROTAC‐Enhanced Cancer Chemo‐Metalloimmunotherapy

Advanced Science, EarlyView.
Schematic overview of PROTAC‐enhanced chemo‐metalloimmunotherapy, integrating senescence induction, multi‐modal STING pathway activation, PD‐L1 blockade, and immune amplification via coordinated PROTACs, metal ions, and chemotherapy to elicit robust antitumor immunity and circumvent immune evasion.
Zhenzhen Chen, Zhe Feng, Siyuan Wang, Jingjing Zhang   +3 more
wiley   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System

Advanced Science, EarlyView.
T cell membrane‐coated MgCO3/Fe‐CD nanozyme loaded with TEPP‐46 (TFMP) enhances breast cancer radioimmunotherapy by reprogramming mitochondrial metabolism in T cells and tumors. It targets PD‐L1, converts H2O2 into ROS, neutralizes acidity, and releases Mg2⁺/TEPP‐46 to boost T cell activation.
Hanyu Zhang, Yuhan Deng, Yantong Lu, Miao Wang, Kun Qiao, Zifan Yang, Shipeng Ning, Tong Liu   +7 more
wiley   +1 more source

Early Administration of N-Acetylcysteine Provides Renal and Cardiac Mitochondrial and Redox Protection, Preventing the Development of Cardio-Renal Syndrome Type IV Induced by 5/6NX. [PDF]

Antioxidants (Basel)
Peralta-Buendía K, Cuevas-López B, García-Arroyo FE, Díaz-Rojas M, León-Contreras JC, Silva-Palacios A, Gonzaga G, Tapia E, Saavedra E, Hernández-Pando R, Pedraza-Chaverri J, Sánchez-Lozada LG, Aparicio-Trejo OE.   +12 more
europepmc   +1 more source

The FhaB Prodomain of Bordetella Affects the Biogenesis of Filamentous Hemaggluttinin, Influencing Bordetella Virulence

, 2012
Christopher R. Noël
openalex   +2 more sources

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

Advanced Science, EarlyView.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan‐Tao Lin, Zhilong Wang, Mei X. Wu   +9 more
wiley   +1 more source

NAT10 induces N4-acetylcytidine modification of AdipoR1-mediated mitochondrial biogenesis against endothelial-to-mesenchymal transition in hypertension. [PDF]

Mol Med
Pan H, Song L, Cheng Z, Zhu J, Zhou J, Xu Z, Zhang M.   +6 more
europepmc   +1 more source

Genetic and epigenetic association studies suggest a role of microRNA biogenesis gene exportin-5 (XPO5) in breast tumorigenesis.

, 2011
Derek Leaderer, Aaron E. Hoffman, Tongzhang Zheng, Alan Fu, Joanne B. Weidhaas, Trupti Paranjape, Yongxue Zhu   +6 more
openalex   +1 more source

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

Advanced Science, EarlyView.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu, Jiamin Sun, Zuyang Jia, Yalei Cui, Xiaoyan Zhu, Zhichang Wang, Hao Sun, Boshuai Liu, Yinghua Shi   +8 more
wiley   +1 more source