Bioguided Isolation and Structure Identification of Acetylcholinesterase Enzyme Inhibitors from Drynariae Rhizome [PDF]
Journal of Analytical Methods in Chemistry, 2020 Drynariae Rhizome, widely distributed in southern China, was clinically used as a traditional treatment for cognitive disfunction, such as Alzheimer’s disease (AD).
Ming-Yang Liu +5 more
doaj +7 more sources
Bioguided isolation of potential antitumor agents from the aerial parts of cultivated cardoon (Cynara cardunculus var. altilis) [PDF]
Saudi Pharmaceutical Journal, 2023 Hepatocellular carcinoma (HCC) is one of the leading causes of mortality worldwide; therefore, searching for an effective treatment for this illness is of great importance.
Rasha A. Hamza +8 more
doaj +4 more sources
Bioguided Isolation of Antibiofilm and Antibacterial Pregnane Glycosides from Caralluma quadrangula: Disarming Multidrug-Resistant Pathogens [PDF]
Antibiotics, 2021 Methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDRAB) present a serious challenge because of their capability to cause biofilm resistance to commonly used antibiotics producing chronic infections and ...
Riham A. El-Shiekh +3 more
doaj +5 more sources
Bioguided Isolation of Alkaloids and Pharmacological Effects of the Total Alkaloid Fraction from Aspidosperma pyrifolium Mart. (Apocynaceae) [PDF]
Plants, 2021 Aspidosperma pyrifolium is used in traditional medicine to treat inflammatory disorders. The aim of the study was to perform phytochemical characterization and evaluate the anti-inflammatory, anti-nociceptive and acute toxicity effects of the total ...
Francisca Sabrina Vieira Lins +4 more
doaj +5 more sources
Bioguided isolation and characterization of bioactives from Polygonum alpinum all rhizomes
Pharmacological Research - Modern Chinese Medicine, 2022 Polygonum alpinum All (Polygonaceae) rhizomes was loaded in soxhlet for extraction with methanol and water as solvent. The extracts obtained were assayed for anti-inflammatory potency via carrageenan and formaldehyde prompted infection among experimental
Prince Ahad Mir +5 more
doaj +2 more sources
Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 Mpro Inhibitors from Penicillium citrinum TDPEF34 [PDF]
Biomolecules, 2021 SARS-CoV-2 virus mutations might increase its virulence, and thus the severity and duration of the ongoing pandemic. Global drug discovery campaigns have successfully developed several vaccines to reduce the number of infections by the virus.
Bathini Thissera +10 more
doaj +2 more sources
Isolation of potent antileishmanial agents from Artemisia kermanensis Podlech using bioguided fractionation. [PDF]
J Parasit Dis, 2023 Abstract Leishmaniasis is a major health problem worldwide with different clinical forms that depend on the parasite, the host's immune system, and immune-inflammatory responses. This study aimed to evaluate the secondary metabolites from Artemisia kermanensis Podlech by bioguided fractionation against Leishmania major.
Soleimanifard S +2 more
europepmc +3 more sources
Furanocoumarins from Ruta chalepensis with Amebicide Activity [PDF]
Molecules, 2021 Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries.
Aldo Fabio Bazaldúa-Rodríguez +5 more
doaj +2 more sources
Bioorganic Chemistry, 2022 Oxidative stress is linked to several invasive diseases which causes significant clinical and economic impact, therefore, there is a need to develop new antioxidants. The natural products could play an important role in overcoming the current need. In the present work, the antioxidant bioassay-guided fractionation of the ethanolic extract of Inula ...
JOSÉ E Piñero +2 more
exaly +4 more sources
UHPLC-QTOF-ESI-MS/MS, SNAP-MS Identification, In Silico Prediction of Pharmacokinetic Properties of Constituents from the Stem Bark of Holarrhena floribunda (G. Don) T. Durand and Schinz (Apocynaceae) [PDF]
BiomoleculesThe present work reports the bioguided isolation of constituents from the ethanol extract of Holarrhena floribunda stem bark, their identification by UHPLC-ESI-QTOF-MS/MS identification, and the in silico prediction of the pharmacokinetic and toxicity ...
Franck Landry Djila Possi +11 more
doaj +2 more sources