Results 41 to 50 of about 257,337 (308)

A novel Cuprotosis-related signature predicts the prognosis and selects personal treatments for melanoma based on bioinformatics analysis

Frontiers in Oncology, 2023
BackgroundMelanoma is a common and aggressive cutaneous malignancy characterized by poor prognosis and a high fatality rate. Recently, due to the application of Immune–checkpoint inhibitors (ICI) in melanoma treatment, melanoma patients’ prognosis has ...
Bingqian Hu, Alphonse Houssou Hounye, Zheng Wang, Min Qi, Jianglin Zhang, Jianglin Zhang   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ironing out the conflicts: iron supplementation reduces negatives bacterial interactions in the rhizosphere of an Atacama-endemic perennial grass

Environmental Microbiome
Background In plants, root exudates selectively influence the growth of bacteria that colonize the rhizosphere. Bacterial communities associated with root systems are involved in macro and micronutrients cycling and organic matter transformation.
Constanza Aguado-Norese, Jonathan E. Maldonado, Christian Hodar, Gabriel Galvez, Daniel E. Palma, Verónica Cambiazo, Mauricio Gonzalez   +6 more
doaj   +1 more source

New classifications for quantum bioinformatics: Q-bioinformatics, QCt-bioinformatics, QCg-bioinformatics, and QCr-bioinformatics

Briefings in Bioinformatics
Abstract Bioinformatics has revolutionized biology and medicine by using computational methods to analyze and interpret biological data. Quantum mechanics has recently emerged as a promising tool for the analysis of biological systems, leading to the development of quantum bioinformatics.
Majid Mokhtari, Samane Khoshbakht, Kobra Ziyaei, Mohammad Esmaeil Akbari, Sayyed Sajjad Moravveji   +4 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis

Frontiers in Endocrinology, 2020
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Epidemiological findings revealed that women with PCOS are prone to develop certain cancer types due ...
Verónica Yumiceba, Andrés López-Cortés, Andrés López-Cortés, Andy Pérez-Villa, Iván Yumiseba, Santiago Guerrero, Jennyfer M. García-Cárdenas, Isaac Armendáriz-Castillo, Patricia Guevara-Ramírez, Paola E. Leone, Ana Karina Zambrano, César Paz-y-Miño   +11 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

TruncTrimmer: A First Step Towards Automating Standard Bioinformatic Analysis [PDF]

, 2021
Bioinformatic analysis is a time-consuming process for labs performing research on various microbiomes. Researchers use tools like Qiime2 to help standardize the bioinformatic analysis methods, but even large, extensible platforms like Qiime2 have ...
Lawless, Z. Gunner, Thompson, Dale R, Ricke, Steven C, Dittoe, Dana   +3 more
core   +2 more sources

Immunoinformatics-Based development of a Multi-Epitope vaccine candidate targeting coinfection by Klebsiella pneumoniae and Acinetobacter baumannii

BMC Infectious Diseases
Background The increasing prevalence of multidrug-resistant (MDR) pathogens in clinical settings underscores the urgent need for effective therapeutic strategies. Among these, ESKAPE pathogens such as Acinetobacter baumannii and Klebsiella pneumoniae are
Gul Afshan, Namrah Yaseen, Syed H Ali, Asad U. Khan   +3 more
doaj   +1 more source

Proteomic and metabolomic analyses reveal the novel targets of spermine for alleviating diabetic cardiomyopathy in type II diabetic mice

Frontiers in Cardiovascular Medicine, 2022
Diabetic cardiomyopathy (DCM) is one of the most serious complications of diabetes. Recent cardiology studies suggest that spermine has a cardioprotective effect.
Jian Sun, Jiyu Xu, Yong Liu, Xiaoyi Xu, Shumin Zhang, Yankun Hao, Yitong Lin, Yue Han, Feiya Li, Hui Yuan, Hui Yuan   +10 more
doaj   +1 more source