Results 91 to 100 of about 280,000 (306)

Is “bioinformatics” dead?

PLOS Biology, 2021
Why would a computational biologist with 40 years of research experience say bioinformatics is dead? The short answer is, in being the Founding Dean of a new School of Data Science, what we do suddenly looks different.
openaire   +4 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part6

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Baker, Allan, Grayson, Phil, Clamp, Michele, Phil Grayson (3294831), Edwards, Scott, Alison Cloutier (3242235), Scott Edwards (587488), Cloutier, Alison, Michele Clamp (6557069), Allan Baker (6323504), Sackton, Timothy   +11 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Characterization of the function and clinical value of ERCC family genes in lung adenocarcinoma

Frontiers in Oncology
IntroductionERCC genes, responsible for encoding enzymes involved in base excision repair, have been implicated in various cancers, contributing to chemoresistance.
Zhimin Lu, Guoxin Hou
doaj   +1 more source

Promising Potential of Lonchocarpus utilis against South American Myasis

Plants, 2019
Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare.
Carmen X. Luzuriaga-Quichimbo, José Blanco-Salas, Carlos E. Cerón-Martínez, Juan Carlos Alías-Gallego, Trinidad Ruiz-Téllez   +4 more
doaj   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part14

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Phil Grayson (3294831), Alison Cloutier (3242235), Scott Edwards (587488), Michele Clamp (6557069), Allan Baker (6323504)   +5 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part4

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Phil Grayson (3294831), Alison Cloutier (3242235), Scott Edwards (587488), Michele Clamp (6557069), Allan Baker (6323504)   +5 more
core   +1 more source

Bioinformatic Pipeline for designing conditional guide RNAs

, 2023
Supplemental files for graduate thesis containing genbank files of plasmid constructs used and bioinformatic tools used for design of conditional guide ...
Chen, Zhewei
core   +1 more source