Results 61 to 70 of about 280,000 (306)

Innovative Hybrid-Alignment Annotation Method for Bioinformatics Identification and Functional Verification of a Novel Nitric Oxide Synthase in Trichomonas vaginalis

Biology, 2022
Both the annotation and identification of genes in pathogenic parasites are still challenging. Although, as a survival factor, nitric oxide (NO) has been proven to be synthesized in Trichomonas vaginalis (TV), nitric oxide synthase (NOS) has not yet been
Hung-Che Lin, Hao-Ai Shui, Kuo-Yang Huang, Wei-Zhi Lin, Hsin-Yi Chang, Hwei-Jen Lee, Ying-Chih Lin, Yuahn-Sieh Huang, Guan-Ru Chen, Ya-Ting Yang, Hsiu-Lin Liu, Yi-Syuan Wu, Chia-Shiang Cheng, Ching-Lung Ko, Yu-Tien Chang, Jih-Chin Lee, Chen-Shien Lin, Chih-Hung Wang, Chi-Ming Chu   +18 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Introduction to Bioinformatics

, 2019
How the scientific community looks at molecular biology today is very different from that 50 years ago. During this time technological developments have led to many significant findings that have shook one of the most important foundations of molecular biology: the central dogma.
AYYILDIZ, DILARA, Piazza S.
openaire   +3 more sources

Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification

Frontiers in Endocrinology
BackgroundLipodystrophy is a rare disease that is poorly diagnosed due to its low prevalence and frequent phenotypic heterogeneity. The main therapeutic measures for patients with clinical lipodystrophy are aimed at improving general metabolic ...
Zhiwen Cao, Zhiwen Cao, Yuxiao Zhao, Yuxiao Zhao, Ruixin Liu, Ruixin Liu, Xialin Yan, Jiqiu Wang, Jiqiu Wang, Na Chen   +9 more
doaj   +1 more source

Low Expression of PLAT in Breast Cancer Infers Poor Prognosis and High Immune Infiltrating Level

International Journal of General Medicine, 2021
Xinyang Wang,1,* Dandan Xue,1,* Xiaoxia Zhu,2,* Rui Geng,3 Xin Bao,2 Xiang Chen,2 Tiansong Xia1,4 1Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department ...
Wang X, Xue D, Zhu X, Geng R, Bao X, Chen X, Xia T   +6 more
doaj  

Patent Data for Comparative Study: Case study of Top Aspirants in Bioinformatics Industry

International Journal of Innovation, 2018
Innovation and technology are considered as a subject of success and achievement to the firm. The comparative study represents an essential procedure to identify the innovation and technological capabilities of major players involved in the ...
Neha Mago, Nishad Deshpande
doaj   +1 more source

Bioinformatic approaches for genome finishing [PDF]

, 2011
Husemann P, Tauch A. Bioinformatic approaches for genome finishing.
Husemann, Peter, Tauch, Andreas
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Bioinformatic analysis ofp53 response in vivo.

, 2003
Bioinformatic analysis ofp53 response in ...
Vadim. Krivokrysenko (7961858)
core   +2 more sources

On Bioinformatic Resources

Genomics, Proteomics & Bioinformatics, 2015
A starting point of curating bioinformatic resources for the public is marked by the establishment of the US National Center for Biotechnology Information (NCBI) in 1988 [1]. One of its many purposes is certainly to echo the initiative of the Human Genome Project (HGP) –– when two landmark reports were published at the same time: “Mapping and ...
openaire   +4 more sources