Results 51 to 60 of about 213,652 (265)

The Roots of Bioinformatics

PLoS Computational Biology, 2010
Every new scientific discipline or methodology reaches a point in its maturation where it is fruitful for it to turn its gaze inward, as well as backward. Such introspection helps to clarify the essential structure of a field of study, facilitating communication, pedagogy, standardization, and the like, while retrospection aids this process by ...
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Introduction to Bioinformatics

, 2019
How the scientific community looks at molecular biology today is very different from that 50 years ago. During this time technological developments have led to many significant findings that have shook one of the most important foundations of molecular biology: the central dogma.
AYYILDIZ, DILARA, Piazza S.
openaire   +3 more sources

Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics

Journal of Fungi, 2023
Fungal infections represent a serious global health problem, causing damage to health and the economy on the scale of millions. Although vaccines are the most effective therapeutic approach used to combat infectious agents, at the moment, no fungal ...
Moisés Morais Inácio, André Luís Elias Moreira, Vanessa Rafaela Milhomem Cruz-Leite, Karine Mattos, Lana O’Hara Souza Silva, James Venturini, Orville Hernandez Ruiz, Fátima Ribeiro-Dias, Simone Schneider Weber, Célia Maria de Almeida Soares, Clayton Luiz Borges   +10 more
doaj   +1 more source

Freedom in bioinformatics [PDF]

Frontiers in Genetics, 2014
1 Institut de Biologie Integrative et des Systemes, Universite Laval, Quebec City, QC, Canada 2 Departement de Biochimie, de Microbiologie et de Bio-informatique, Faculte des Sciences et de Genie, Universite Laval, Quebec City, QC, Canada 3 Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, QC ...
Antony T Vincent, Antony T Vincent, Antony T Vincent, Steve J Charette, Steve J Charette, Steve J Charette   +5 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

mAbs, 2020
The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavorable
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick   +8 more
doaj   +1 more source

Innovative Hybrid-Alignment Annotation Method for Bioinformatics Identification and Functional Verification of a Novel Nitric Oxide Synthase in Trichomonas vaginalis

Biology, 2022
Both the annotation and identification of genes in pathogenic parasites are still challenging. Although, as a survival factor, nitric oxide (NO) has been proven to be synthesized in Trichomonas vaginalis (TV), nitric oxide synthase (NOS) has not yet been
Hung-Che Lin, Hao-Ai Shui, Kuo-Yang Huang, Wei-Zhi Lin, Hsin-Yi Chang, Hwei-Jen Lee, Ying-Chih Lin, Yuahn-Sieh Huang, Guan-Ru Chen, Ya-Ting Yang, Hsiu-Lin Liu, Yi-Syuan Wu, Chia-Shiang Cheng, Ching-Lung Ko, Yu-Tien Chang, Jih-Chin Lee, Chen-Shien Lin, Chih-Hung Wang, Chi-Ming Chu   +18 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Left ventricular assist device bioinformatics identify possible hubgenes and regulatory networks involved in the myocardium of patients with left ventricular assist device

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThe aim of this study was to clarify the changes of myocardial gene expression profile after left ventricular assist device (LVAD) implantation and the related molecular biological significance.MethodsA thorough bioinformatic analysis to ...
Maryam Ajmal, Aisha Ajmal, Maryam Rizvi, Umar Salim, Lei Huang, Lei Huang, Lei Huang, Lei Huang   +7 more
doaj   +1 more source