Results 61 to 70 of about 213,652 (265)

microRNA Bioinformatics

Cells, 2022
Firstly, I apologize for the delayed publication of this Special Issue in the form of a book title [...]
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification

Frontiers in Endocrinology
BackgroundLipodystrophy is a rare disease that is poorly diagnosed due to its low prevalence and frequent phenotypic heterogeneity. The main therapeutic measures for patients with clinical lipodystrophy are aimed at improving general metabolic ...
Zhiwen Cao, Zhiwen Cao, Yuxiao Zhao, Yuxiao Zhao, Ruixin Liu, Ruixin Liu, Xialin Yan, Jiqiu Wang, Jiqiu Wang, Na Chen   +9 more
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Low Expression of PLAT in Breast Cancer Infers Poor Prognosis and High Immune Infiltrating Level

International Journal of General Medicine, 2021
Xinyang Wang,1,* Dandan Xue,1,* Xiaoxia Zhu,2,* Rui Geng,3 Xin Bao,2 Xiang Chen,2 Tiansong Xia1,4 1Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department ...
Wang X, Xue D, Zhu X, Geng R, Bao X, Chen X, Xia T   +6 more
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Patent Data for Comparative Study: Case study of Top Aspirants in Bioinformatics Industry

International Journal of Innovation, 2018
Innovation and technology are considered as a subject of success and achievement to the firm. The comparative study represents an essential procedure to identify the innovation and technological capabilities of major players involved in the ...
Neha Mago, Nishad Deshpande
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

On Bioinformatic Resources

Genomics, Proteomics & Bioinformatics, 2015
A starting point of curating bioinformatic resources for the public is marked by the establishment of the US National Center for Biotechnology Information (NCBI) in 1988 [1]. One of its many purposes is certainly to echo the initiative of the Human Genome Project (HGP) –– when two landmark reports were published at the same time: “Mapping and ...
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Determination of Physicochemical Properties of Human Immunoglobulin G- Fc Fragment by Bioinformatic

فصلنامه دانشگاه علوم پزشکی جهرم, 2021
Introduction: Immunoglobulins (Igs) are defensive glycoproteins specifically recognize and destroy pathogens. Immunoglobulin G (IgG) is most abundant Ig in serum has important protective role against infections. Fragment of crystallizable (Fc) in IgG has
Soheyla Rohani, Fatemeh Hajighasemi
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