Results 161 to 170 of about 782,783 (305)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Detecting unannotated splicing events in short-read RNA-seq with SAMI, a UMI-aware Nextflow pipeline. [PDF]

Bioinformatics
Mareschal S, Wucher V, Huet S, Léonce C, Chabane K, Hayette S, Bringuier PP, Pinson S, Barritault M, Bardel C.   +9 more
europepmc   +1 more source

Genetic Algorithm for Random Tree Generation in Bioinformatics Data

In the last few decades the progress in medical technology has made it possible to analyze biologic material like DNA, protein profiles and antibody displays.
Poļaka, Inese
core  

Bioinformatics Activity Bank

, 2012
This resource is designed for educators hoping to teach students about the world of biotechnology and bioinformatics, and the lesson plans here are top-notch.

core  

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

PULPO: pipeline of understanding large-scale patterns of oncogenomic signatures. [PDF]

Bioinformatics
Portasany-Rodríguez M, Soria-Alcaide G, Sánchez EG, Ivanova M, Gómez A, Giménez R, Lalchandani J, García-Aguilera G, Alemán-Arteaga S, Saiz-Ladera C, Ramírez-Orellana M, Garcia-Martinez J.   +11 more
europepmc   +1 more source

The growth of bioinformatics [PDF]

Briefings in Bioinformatics, 2006
openaire   +2 more sources

A study on the elementary school teachers' attitudes toward bioinformatics in Tainan County － based on Taiwan Biobank

, 2010
[[abstract]]This research aims to investigate elementary school teacher’s attitudes toward bioinformatics. The subjects were selected mainly from elementary teachers of Tainan County, and the research was conducted by the method of purposive sampling ...
wan ju Lee
core  

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source