Results 171 to 180 of about 1,289,019 (331)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

The Potential of Bioinformatics in Revolutionizing Disease Diagnosis in Sub-Saharan Africa: A Narrative Review. [PDF]

Health Sci Rep
Ofosu W, Kotey FCN, Odoom A, Ntim OK, Donkor ES.   +4 more
europepmc   +1 more source

ImmunoNX: a robust bioinformatics workflow to support personalized neoantigen vaccine trials

Singhal, Kartik, Schmidt, Evelyn, Kiwala, Susanna, Goedegebuure, S. Peter, Miller, Christopher A., Xia, Huiming, Cotto, Kelsy C., Li, Jinglun, Yao, Jennie, Hendrickson, Luke, Richters, Miller M., Hoang, My H., Khanfar, Mariam, Risch, Isabel, O'Laughlin, Shelly, Myers, Nancy, Vickery, Tammi, Davies, Sherri R., Du, Feiyu, Mooney, Thomas B., Coffman, Adam, Chang, Gue Su, Hundal, Jasreet, Garza, John E., McLellan, Michael D., McMichael, Joshua F., Maruska, John, Inabinett, William Blake, Hoos, William A., Karchin, Rachel, Johanns, Tanner M., Dunn, Gavin P., Pachynski, Russel K., Fehniger, Todd A., Ward, Jeffrey P., Foltz, Jennifer A., Gillanders, William E., Griffith, Obi L., Griffith, Malachi   +38 more
openalex   +1 more source

Bioinformatic pipeline for studying transcriptome and regulome dynamics during neural differentiation v3

, 2018
Zhouchun Shang, Dongsheng Chen, Quanlei Wang, Shengpeng Wang   +3 more
openalex   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Reframing bioinformatics capacity development in Africa: from training supply to research-driven demand. [PDF]

J Community Genet
Hussein J, Myovela H.
europepmc   +1 more source

Additional file 3 of Integrated bioinformatics analysis for conducting a prognostic model and identifying immunotherapeutic targets in gastric cancer

, 2023
YaLing Liu, Dan Li, Yong Chen, Yijuan Liu, YiJuan Lin, XunRu Huang, Ting Wu, Chengdang Wang, Jian Ding   +8 more
openalex   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Evolutionary Bioinformatics Expands its Breadth. [PDF]

Evol Bioinform Online
Caetano-Anollés G.
europepmc   +1 more source

Personal Genomics, Bioinformatics, and Variomics [PDF]

, 2008
Jong Bhak, Ho Ghang, Rohit Reja, Sangsoo Kim   +3 more
openalex   +1 more source