Results 191 to 200 of about 840,775 (293)

Correction: Approximating facial expression effects on diagnostic accuracy via generative AI in medical genetics. [PDF]

Bioinformatics
europepmc   +1 more source

A course-undergraduate research experience (CURE) to explore the effect of structural variants on gene expression in C. elegans balancers. [PDF]

PLoS One
Maroilley T, Barbosa VRA, Mascarenhas R, Ferris S, Diao C, AlAwadhi F, Aldakheel S, Ali A, Alkanderi D, Alshatti M, Alsuwaileh S, Bui R, Chai B, Dsouza L, Nezhad PE, Garcia-Volk E, Haq Z, Hossain S, Johnson G, Kotikalapudi N, Lalani I, Lenz C, Louie T, Moore S, Patel S, Prasai S, Qureshi R, Rahmani F, Shakir B, Ahamed SS, Tran HA, Waziha R, Wood CM, Zbinden S, Anderson D, Tarailo-Graovac M.   +35 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Correction: MS-ConTab: multi-scale contrastive learning of mutation signatures for Pan-Cancer representation and stratification. [PDF]

Bioinformatics
europepmc   +1 more source

Correction: Network-based integrative analysis of multi-level regulatory mechanisms associated with glyphosate exposure. [PDF]

Front Bioinform
Consuegra-Mayor C, Arroyo-Salgado B, Olivero-Verbel J.   +2 more
europepmc   +1 more source

Correction to: Semantic-enhanced heterogeneous graph learning for identifying ncRNAs associated with drug resistance. [PDF]

Bioinformatics
europepmc   +1 more source

DESpace2: detection of differential spatial patterns in spatial omics data. [PDF]

Bioinformatics
Cai P, Robinson MD, Tiberi S.
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

map3C: a computational tool for processing multiomic single-cell Hi-C data. [PDF]

Bioinformatics
Galasso J, Wang Y, Alber F, Ernst J, Luo C.   +4 more
europepmc   +1 more source