Results 201 to 210 of about 1,289,019 (331)

VDJ-Insights: simplifying the annotation of genomic immunoglobulin and T cell receptor regions. [PDF]

Bioinformatics
Ott SE, Le GN, Mohammadi SJ, Mittertreiner J, Pasini EM, Bontrop RE, de Groot NG, Bruijnesteijn J.   +7 more
europepmc   +1 more source

Bioinformatic estimate of biomarker-positive populations in genomics-driven trials using precision trial designer (PTD) [PDF]

, 2017
Luca Mazzarella, G. Melloni, Alessandro Guida, Giuseppe Curigliano, Edoardo Botteri, Alessandro Esposito, Maud Kamal, C. Le Tourneau, Laura Riva, Pier Giuseppe Pelicci   +9 more
openalex   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Bioinformatic analysis of RNA from diverse species

, 2014
Ambarish Biswas
openalex   +1 more source

Neptune: a bioinformatics tool for rapid discovery of genomic variation in bacterial populations [PDF]

, 2017
Eric Marinier, Rahat Zaheer, Chrystal Berry, Kelly Weedmark, Michael Domaratzki, Philip Mabon, Natalie Knox, Aleisha Reimer, Morag Graham, Linda Chui, Laura Patterson-Fortin, Jian Zhang, Franco Pagotto, Jeff Farber, J B Mahony, Karine Seyer, Sadjia Békal, Cécile Tremblay, Judy Isaac-Renton, Natalie Prystajecky, Jessica Chen, Peter G. Slade, Gary Van Domselaar   +22 more
openalex   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

SpliceHarmonization: an integrated method for identifying RNA splicing events in therapeutics for splicing modulation. [PDF]

Bioinformatics
Chen Y, Zhang H, Sun YH, Negi S, Cao S, Ouyang Z, Zhang B, Hurt J, Huh D.   +8 more
europepmc   +1 more source

Bioinformatic analysis of antivirus‐related TRIM genes in Dabry’s sturgeon Acipenser dabryanus [PDF]

, 2018
Youshen Li, Shuhuan Zhang, Panpan Han, Kai Luo, Wei Hu, Wenbing Zhang, Qiaoqing Xu, Qiwei Wei   +7 more
openalex   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Evaluating deep learning based structure prediction methods on antibody-antigen complexes. [PDF]

Bioinformatics
Fromm S, Ludaic M, Elofsson A.
europepmc   +1 more source