Results 231 to 240 of about 1,243,490 (281)

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

InterVelo: a mutually enhancing model for estimating pseudotime and RNA velocity in multi-omic single-cell data. [PDF]

Bioinformatics
Wang Y, Lin Z, Wang T.
europepmc   +1 more source

An Integrative Bioinformatics Approach to Investigating TIMP3 and Immune Cell Infiltration: Prognostic and Clinicopathological Implications [PDF]

Neelam Bhola, Amit K. Jaiswal, Daman Saluja   +2 more
openalex   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

FIBOS: R and python packages for analyzing protein packing and structure. [PDF]

Bioinformatics
Soares HHM, Romanelli JPR, Fleming PJ, da Silveira CH.   +3 more
europepmc   +1 more source

R Programming for Bioinformatics [PDF]

Jan de Leeuw
core   +1 more source

New aspects of statistical methods for missing data problems, with applications in bioinformatics and genetics

, 2006
Dong Wang
openalex   +2 more sources

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

qcCHIP: an R package to identify clonal hematopoiesis variants using cohort-specific data characteristics. [PDF]

Bioinformatics
Liu X, Tang YH, Blachly J, Edge S, Jakubek YA, McCarter M, Naqash AR, Nepple KG, Osman A, Reilley MJ, Riedlinger G, Salhia B, Schneider BP, Shriver C, Churchman ML, Rounbehler RJ, Teer JK, Gillis N, Teng M.   +18 more
europepmc   +1 more source

Mathematical Bioinformatics [PDF]

, 2015

core