Results 231 to 240 of about 1,268,351 (323)

BioAgents: Bridging the gap in bioinformatics analysis with multi-agent systems. [PDF]

open access: yesSci Rep
Mehandru N   +8 more
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

open access: yesAdvanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin   +14 more
wiley   +1 more source

PLAID: ultrafast single-sample gene set enrichment scoring. [PDF]

open access: yesBioinformatics
Zito A   +5 more
europepmc   +1 more source

Exploring shared biomarkers and shared pathways in insomnia and atherosclerosis using integrated bioinformatics analysis

open access: gold
Qichong Yang   +9 more
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

open access: yesAdvanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye   +7 more
wiley   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

open access: yesAdvanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu   +7 more
wiley   +1 more source

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