Results 41 to 50 of about 1,236,826 (322)

Educating the educators: Incorporating bioinformatics into biological science education in Malaysia [PDF]

, 2012
Bioinformatics can be defined as a fusion of computational and biological sciences. The urgency to process and analyse the deluge of data created by proteomics and genomics studies has caused bioinformatics to gain prominence and importance. However, its
Hussein, Huszalina, Mohd. Hashim, Siti Zaiton, Salim, Naomie, Shamsir, Mohd. Shahir   +3 more
core  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus

Journal of Nanobiotechnology, 2023
The outbreak of the monkeypox virus (MPXV) worldwide in 2022 highlights the need for a rapid and low-cost MPXV detection tool for effectively monitoring and controlling monkeypox disease.
Xingsheng Yang, Xiaodan Cheng, Hongjuan Wei, Zhijie Tu, Zhen Rong, Chongwen Wang, Shengqi Wang   +6 more
doaj   +1 more source

Algebraic Comparison of Partial Lists in Bioinformatics [PDF]

, 2010
The outcome of a functional genomics pipeline is usually a partial list of genomic features, ranked by their relevance in modelling biological phenotype in terms of a classification or regression model.
A Gobbi, A Kalousis, A Kossenkov, A Sboner, AC Haury, AL Boulesteix, Arkady B. Khodursky, B Di Camillo, B Efron, B Efron, B Efron, B Schowe, C Cortes, C Cortes, C Furlanello, C Schneider, C Schneider, C Soneson, C Yao, Cesare Furlanello, Consortium The MicroArray Quality Control (MAQC), D Albanese, D Cai, D Corrada, D Critchlow, D Saari, D Witten, G Guzzetta, G Jurman, G Jurman, G Lance, G Lance, G Smyth, Giuseppe Jurman, GS Cheon, I Guyon, I Jeffery, I Lönnstedt, J Bar-Ilan, J Borda, J Chen, J Ioannidis, J Neter, J Storey, L Ein-Dor, L Kuncheva, L Yu, L Zhang, M Desarkar, M Kauers, M Kauers, M Kendall, M Schimek, M Schimek, M Slawski, M Villarino, M Villarino, O Bousquet, P Baldi, P Diaconis, P Diaconis, P Hall, P Hall, P Krízek, PC Boutros, R Fagin, R Gentleman, R Graham, R Pearson, R Pique-Regi, R Pique-Regi, R Simon, Roberto Visintainer, S Abramov, S Dudoit, S Lin, S Lin, S Mukherjee, S Setlur, S Simićc, S Vanderlooy, Samantha Riccadonna, SK Lau, T Bø, T Calders, V Tusher, Visintainer, W Fury, W Hoeffding, W Shi, X Wang, X Yang, Y Xiao, Y Xiao, Z He   +94 more
core   +4 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Simulated single molecule microscopy with SMeagol

, 2016
SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation, and optimization of advanced analysis methods for live cell single molecule microscopy data ...
Boucharin, Alexis, Elf, Johan, Fange, David, Lindén, Martin, Ćurić, Vladimir   +4 more
core   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Fostering bioinformatics education through skill development of professors: Big Genomic Data Skills Training for Professors.

PLoS Computational Biology, 2019
Bioinformatics has become an indispensable part of life science over the past 2 decades. However, bioinformatics education is not well integrated at the undergraduate level, especially in liberal arts colleges and regional universities in the United ...
Yingqian Ada Zhan, Charles Gregory Wray, Sandeep Namburi, Spencer T Glantz, Reinhard Laubenbacher, Jeffrey H Chuang   +5 more
doaj   +1 more source

Bioinformatics and the eye [PDF]

Journal of Ocular Biology, Diseases, and Informatics, 2009
Bioinformatics evolved to become a recognized scientific discipline during the last decade of the twentieth century, due in part to the Human Genome Project and the introduction of microarray expression profiling, both of which involved critical computational activities.
openaire   +3 more sources

GPU cards as a low cost solution for efficient and fast classification of high dimensional gene expression datasets [PDF]

, 2010
The days when bioinformatics tools will be so reliable to become a standard aid in routine clinical diagnostics are getting very close. However, it is important to remember that the more complex and advanced bioinformatics tools become, the more ...
Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco Michele Maria, Savino, Alessandro, Scionti, A.   +4 more
core