Results 31 to 40 of about 840,775 (293)

Predicting enhancers with deep convolutional neural networks

BMC Bioinformatics, 2017
Background With the rapid development of deep sequencing techniques in the recent years, enhancers have been systematically identified in such projects as FANTOM and ENCODE, forming genome-wide landscapes in a series of human cell lines.
Xu Min, Wanwen Zeng, Shengquan Chen, Ning Chen, Ting Chen, Rui Jiang   +5 more
doaj   +1 more source

Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus

Journal of Nanobiotechnology, 2023
The outbreak of the monkeypox virus (MPXV) worldwide in 2022 highlights the need for a rapid and low-cost MPXV detection tool for effectively monitoring and controlling monkeypox disease.
Xingsheng Yang, Xiaodan Cheng, Hongjuan Wei, Zhijie Tu, Zhen Rong, Chongwen Wang, Shengqi Wang   +6 more
doaj   +1 more source

Over-optimism in bioinformatics: an illustration [PDF]

, 2010
In statistical bioinformatics research, different optimization mechanisms potentially lead to "over-optimism" in published papers. The present empirical study illustrates these mechanisms through a concrete example from an active research field.
Arthur, Tenenhaus, Arthur Tenenhaus, Strimmer, Korbinian, Strimmer, K., Boulesteix, Anne-Laure, Monika, Jelizarow, Vincent Guillemot, Vincent, Guillemot, Tenenhaus, Arthur, Anne-Laure Boulesteix, Guillemot, Vincent, Monika Jelizarow, Jelizarow, Monika, Korbinian Strimmer, Anne-Laure, Boulesteix, Korbinian, Strimmer   +15 more
core   +1 more source

XML schemas for common bioinformatic data types and their application in workflow systems [PDF]

, 2006
Seibel PN, Krüger J, Hartmeier S, et al. XML schemas for common bioinformatic data types and their application in workflow systems. BMC Bioinformatics.
Krüger, Jan, Seibel Philipp N, Sven Hartmeier, Krüger Jan, Giegerich, R., Philipp N Seibel, Hartmeier Sven, Schwarzer Knut, Henning Mersch, Schwarzer, Knut, Seibel, Philipp N., Knut Schwarzer, Löwenthal Kai, Krüger, J., Dandekar, Th., Robert Giegerich, Giegerich, Robert, Jan Krüger, Dandekar, Thomas, Löwenthal, Kai, Mersch Henning, Hartmeier, S., Thomas Dandekar, Seibel, P. N., Krueger, Jan, Mersch, Henning, Löwenthal, K., Kai Löwenthal, Giegerich Robert, Schwarzer, K., Dandekar Thomas, Hartmeier, Sven, Mersch, H.   +32 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Helab-bioinformatics/CSC_mechanical_force: V1.0.0

, 2023
This is the first ...
Helab-bioinformatics
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Streamlined and on-demand preparation of mRNA products on a universal integrated platform

Microsystems & Nanoengineering, 2023
Vaccines are used to protect human beings from various diseases. mRNA vaccines simplify the development process and reduce the production cost of conventional vaccines, making it possible to respond rapidly to acute and severe diseases, such as ...
Hongjuan Wei, Zhen Rong, Liyan Liu, Ye Sang, Jing Yang, Shengqi Wang   +5 more
doaj   +1 more source