Results 51 to 60 of about 840,775 (293)

Design of a global population-covering multi-epitope mRNA vaccine against Lassa virus using immunoinformatics

Scientific Reports
The Lassa virus (LV) is a hemorrhagic virus that causes Lassa fever (LF). Despite its high mortality rate in Africa, no FDA-approved mRNA vaccine currently exists.
Noimul Hasan Siddiquee, Md Shoyaib Hossan Sami, Md. Aftabur Rahman, Md. Al-Amin, Md. Al-Amin Biswash, Kangkan Sharma, Kutub Uddin Samrat, Md. Ifteker Hossain, Ahmad Abdullah Mahdeen   +8 more
doaj   +1 more source

The Roots of Bioinformatics

PLoS Computational Biology, 2010
Every new scientific discipline or methodology reaches a point in its maturation where it is fruitful for it to turn its gaze inward, as well as backward. Such introspection helps to clarify the essential structure of a field of study, facilitating communication, pedagogy, standardization, and the like, while retrospection aids this process by ...
openaire   +4 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Reproducible bioinformatics project: a community for reproducible bioinformatics analysis pipelines

BMC Bioinformatics, 2018
Background Reproducibility of a research is a key element in the modern science and it is mandatory for any industrial application. It represents the ability of replicating an experiment independently by the location and the operator.
Neha Kulkarni, Luca Alessandrì, Riccardo Panero, Maddalena Arigoni, Martina Olivero, Giulio Ferrero, Francesca Cordero, Marco Beccuti, Raffaele A. Calogero   +8 more
doaj   +1 more source

Community development, implementation, and assessment of a NIBLSE bioinformatics sequence similarity learning resource.

PLoS ONE, 2021
As powerful computational tools and 'big data' transform the biological sciences, bioinformatics training is becoming necessary to prepare the next generation of life scientists. Furthermore, because the tools and resources employed in bioinformatics are
Adam J Kleinschmit, Elizabeth F Ryder, Jacob L Kerby, Barbara Murdoch, Sam Donovan, Nealy F Grandgenett, Rachel E Cook, Chamindika Siriwardana, William Morgan, Mark Pauley, Anne Rosenwald, Eric Triplett, William Tapprich   +12 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Introduction to Bioinformatics

, 2019
How the scientific community looks at molecular biology today is very different from that 50 years ago. During this time technological developments have led to many significant findings that have shook one of the most important foundations of molecular biology: the central dogma.
AYYILDIZ, DILARA, Piazza S.
openaire   +3 more sources

Computational screening of seaweed metabolites as potential antifungal agents against Candida auris

Beni-Suef University Journal of Basic and Applied Sciences
Background Candida auris (C. auris) has emerged as a serious global health threat due to its resistance to antifungal treatments and its persistence in healthcare environments.
Md. Al-Amin, Afsana Mustak Mim, Salman Reja, Samia Sadaf, Md. Younus Shekh, Sabiha Akter, Ive Sithi Chambugong, Shanjida Akter Joyoti, Md. Ifteker Hossain, Noimul Hasan Siddiquee   +9 more
doaj   +1 more source

Preface to Introduction to Protein Structural Bioinformatics [PDF]

, 2018
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics.
Abeln, Sanne, Feenstra, K. Anton, Feenstra, K. Anton; id_orcid, Abeln, Sanne; id_orcid   +3 more
core   +1 more source

A quantitative account of genomic island acquisitions in prokaryotes [PDF]

, 2011
Background Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer.
van Passel, Mark W. J., van Passel Mark WJ, Passel, M.W.J., van, Mark WJ van Passel, Roos Tom E, Roos, T.E., van Passel, M.W.J., Roos, Tom E., Tom E Roos   +8 more
core   +3 more sources