Results 71 to 80 of about 840,775 (293)

From the establishment of a national bioinformatics society to the development of a national bioinformatics infrastructure [version 2; peer review: 1 approved, 2 approved with reservations]

F1000Research
We describe the evolution of a bioinformatics national capacity from scattered professionals into a collaborative organisation, and advancements in the adoption of the bioinformatics infrastructure philosophy by the national community.
Bogdan Mirăuță, Horia L. Banciu, Michalis-Daniel Lazăr, Daria Mihalachi, Mădălina Giurgiu, Marius Mihășan, Monica Abrudan, Cătălina Zenoaga-Barbăroșie   +7 more
doaj   +1 more source

Bioinformatics

, 2019
Our bioinformatic staff consist of PhD-level scientists trained in computer languages, statistics, bioinformatics, genetics, and genomics. The software infrastructure for analysis is a combination of custom-built and open-source software.
Grace Melly (5914202)
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

developing-bioinformatics/bioinformatics: Introduction to Bioinformatics FA2019 v1.0

, 2020
<p>Course notes and code for BIO331 Introduction to Bioinformatics FA2019 at Stonehill College.</p ...
Rob Harbert
core   +1 more source

The Helmholtz Network for Bioinformatics: an integrative web portal for bioinformatics resources

, 2022
S.268-270The Helmholtz Network for Bioinformatics (HNB) is a joint venture of eleven German bioinformatics research groups that offers convenient access to numerous bioinformatics resources through a single web portal.
Crass, T., Christensen, M., Claussen, H., Antes, I., Basekow, W., Bork, P., Buning, C., Gailus-Durner, V., Ernst, P., Ebeling, C.   +9 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Bioinformatics approach to enhance the undergraduate biology students’ understanding of plant terpenoid

JPBI (Jurnal Pendidikan Biologi Indonesia)
Plant metabolite compounds have been applied on plant cellular metabolism, produces organic and inorganic compounds, primary and secondary bioactive molecules, such as glucose, amino acids, fat acids, alkaloids, flavonoids, and terpenoids. Undergraduate
Risanti Dhaniaputri, Hadi Suwono, Betty Lukiati   +2 more
doaj   +1 more source

Is “bioinformatics” dead?

PLOS Biology, 2021
Why would a computational biologist with 40 years of research experience say bioinformatics is dead? The short answer is, in being the Founding Dean of a new School of Data Science, what we do suddenly looks different.
openaire   +4 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source