Results 41 to 50 of about 840,775 (293)

University-level practical activities in bioinformatics benefit voluntary groups of pupils in the last 2 years of school [PDF]

, 2015
This work was supported in part by the Science and Technology Facilities Council under grant ST/M000435/1 to Daniel Barker.Background Bioinformatics—the use of computers in biology—is of major and increasing importance to biological sciences and medicine.
Rosanna G. Alderson, Gavin T. P. Muirhead, Comrie, Muriel H, Heleen Plaisier, Sweeney, Stuart D, Muirhead, Gavin T.P., James L. McDonagh, McDonagh, James L., Stuart D. Sweeney, Sweeney, Stuart D., Alderson, Rosanna G, Muriel M. Comrie, Leigh Duncan, Plaisier, Heleen, Duncan, Leigh, Barker, Daniel, Muirhead, Gavin TP, McDonagh, James L, Daniel Barker, Comrie, Muriel Margaret, Mcdonagh, James, Alderson, Rosanna Grace   +21 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Fostering bioinformatics education through skill development of professors: Big Genomic Data Skills Training for Professors.

PLoS Computational Biology, 2019
Bioinformatics has become an indispensable part of life science over the past 2 decades. However, bioinformatics education is not well integrated at the undergraduate level, especially in liberal arts colleges and regional universities in the United ...
Yingqian Ada Zhan, Charles Gregory Wray, Sandeep Namburi, Spencer T Glantz, Reinhard Laubenbacher, Jeffrey H Chuang   +5 more
doaj   +1 more source

A streamlined platform for analyzing tera-scale DDA and DIA mass spectrometry data enables highly sensitive immunopeptidomics

Nature Communications, 2022
Immunopeptidomics benefits from highly sensitive mass spectrometry (MS). Here, the authors present a computational platform for integrating data-dependent and -independent acquisition MS approaches, and demonstrate its utility for deeper immunopeptidome ...
Lei Xin, Rui Qiao, Xin Chen, Hieu Tran, Shengying Pan, Sahar Rabinoviz, Haibo Bian, Xianliang He, Brenton Morse, Baozhen Shan, Ming Li   +10 more
doaj   +1 more source

Freedom in bioinformatics [PDF]

Frontiers in Genetics, 2014
1 Institut de Biologie Integrative et des Systemes, Universite Laval, Quebec City, QC, Canada 2 Departement de Biochimie, de Microbiologie et de Bio-informatique, Faculte des Sciences et de Genie, Universite Laval, Quebec City, QC, Canada 3 Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, QC ...
Antony T Vincent, Antony T Vincent, Antony T Vincent, Steve J Charette, Steve J Charette, Steve J Charette   +5 more
doaj   +3 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Structural and energetic basis of marine phytochemicals as dengue NS1 protein inhibitors

Scientific Reports
Dengue, spread by Aedes aegypti and Aedes albopictus, causes 390 million infections, 50 million illnesses, and 24,000 fatalities, including over 4.5 million in 2023.
Sanjida Mahjabin Sanju, Md. Meherajul Kabir, Md. Ifteker Hossain, Ahamad Arafat Rizbi, Mehajabin Nusrat Nadia, Jannatul Ferdous, Mst. Ruma Akter, Nazia Kamal, Farhana Mansoor Priya, Noimul Hasan Siddiquee   +9 more
doaj   +1 more source

The Third Annual Meeting of the European Virus Bioinformatics Center [PDF]

, 2019
The Third Annual Meeting of the European Virus Bioinformatics Center (EVBC) took place in Glasgow, United Kingdom, 28–29 March 2019. Virus bioinformatics has become central to virology research, and advances in bioinformatics have led to improved ...
Lycett, Samantha; id_orcid, Robertson, David, Dutilh, B.E., Escalera-Zamudio, M, V Thiel (7788257), Ibrahim, Bashar, Dutilh, Bas E., Clokie, MRJ, Julian Susat, EM Adriaenssens (7707755), Dutilh, Bas E, Escalera-Zamudio, Marina, Simmonds, P, Bas E. Dutilh, Abroi, Aare, Sicheritz, T, T Sicheritz (7788275), Adriaenssens, E.M., Jenna Nicole Kelly, Franziska Hufsky, JN Kelly (7788266), Kelly, Jenna Nicole, Theoretical Biology and Bioinformatics, Bashar Ibrahim, Deinhardt-Emmer, S., Modha, S, M Marz (7788278), Susat, J., Manja Marz, F Hufsky (7788239), Kevin Lamkiewicz, Bas E. Dutilh, Susat, Julian, Evelien M. Adriaenssens, Robertson, DL, Peter Simmonds, David L. Robertson, Deinhardt-Emmer, Stefanie, Robertson, David L, J Susat (7788272), Robertson, D.L., L Lu (4696135), Lu, Lu; id_orcid, Lu, L, Marina Escalera-Zamudio, Ibrahim, B, Lu, Lu, Thiel, V., Escalera-Zamudio, M., Clokie, Martha R. J., Kelly, JN, Thiel, V, Marz, Manja, Modha, S., Clokie, M.R., Lycett, Samantha, Lamkiewicz, Kevin, Samantha Lycett, Kelly, J.N., Volker Thiel, Thomas Sicheritz, Jenna Nicole Kelly, Hufsky, F, Marz, M, Robertson, David L., P Simmonds (7788254), Hufsky, F., Sicheritz, T., Abroi, A, BE Dutilh (7707779), Adriaenssens, Evelien M, S Deinhardt-Emmer (7788248), Sejal Modha, Deinhardt-Emmer, S, Thiel, Volker, Sub Bioinformatics, Lamkiewicz, K, Abroi, A., Evelien M. Adriaenssens, Susat, J, DL Robertson (7656881), Marz, M., Dutilh, BE, Stefanie Deinhardt-Emmer, David L. Robertson, Adriaenssens, Evelien M., Lycett, S., Lycett, S, Lu, L., Clokie, Martha R J, Simmonds, Peter, M Escalera-Zamudio (7788263), S Modha (7788245), Modha, Sejal, Lamkiewicz, K., Lu Lu, Sicheritz, Thomas, MRJ Clokie (7713161), Adriaenssens, EM, Hufsky, Franziska, S Lycett (7788251), A Abroi (7788260), K Lamkiewicz (7788269), Ibrahim, B., Martha R. J. Clokie, Aare Abroi, Martha R. J. Clokie, Simmonds, P., B Ibrahim (7788242)   +108 more
core   +4 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source