Results 81 to 90 of about 1,477,984 (353)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Structural and energetic basis of marine phytochemicals as dengue NS1 protein inhibitors

open access: yesScientific Reports
Dengue, spread by Aedes aegypti and Aedes albopictus, causes 390 million infections, 50 million illnesses, and 24,000 fatalities, including over 4.5 million in 2023.
Sanjida Mahjabin Sanju   +9 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

A combined public health and bioinformatics talent training model and knowledge structure

open access: yesZhongguo gonggong weisheng
Under the "Healthy China" initiative, the development of a robust public health system is a national priority. Bioinformatics methods and technologies are integral to this system, and the integration of public health and bioinformatics plays a crucial ...
Xiangchao FAN   +4 more
doaj   +1 more source

The Genome Solver Project: Faculty Training and Student Performance Gains in Bioinformatics

open access: yesJournal of Microbiology & Biology Education, 2019
Bioinformatics brings together biology, mathematics, statistics, and computer science to analyze biological sequence information. Anyone with a computer, access to the Internet, and basic training in this field can contribute to genomics research.
Vinayak Mathur   +4 more
doaj   +1 more source

Flow cytometry bioinformatics. [PDF]

open access: yesPLoS Computational Biology, 2013
Flow cytometry bioinformatics is the application of bioinformatics to flow cytometry data, which involves storing, retrieving, organizing, and analyzing flow cytometry data using extensive computational resources and tools.
Kieran O'Neill   +3 more
doaj   +1 more source

ExPASy: SIB bioinformatics resource portal

open access: yesNucleic Acids Res., 2012
ExPASy (http://www.expasy.org) has worldwide reputation as one of the main bioinformatics resources for proteomics. It has now evolved, becoming an extensible and integrative portal accessing many scientific resources, databases and software tools in ...
Panu Artimo   +20 more
semanticscholar   +1 more source

Viral bioinformatics

open access: yes, 2008
Pathogens have presented a major challenge to individuals and populations of living organisms, probably as long as there has been life on earth. They are a prime object of study for at least three reasons: (1) Understanding the way of pathogens affords the basis for preventing and treating the diseases they cause. (2) The interactions of pathogens with
Adams, B.   +3 more
openaire   +2 more sources

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