Results 141 to 150 of about 640,321 (318)

myExperiment: a repository and social network for the sharing of bioinformatics workflows [PDF]

myExperiment (http://www.myexperiment.org) is an online research environment that supports the social sharing of bioinformatics workflows. These workflows are procedures consisting of a series of computational tasks using web services performed on data ...
De Roure, David, Aleksejevs, Sergejs, Michaelides, Danius, Roos, Marco, Cruickshank, Don, Bhagat, Jiten, Newman, David, Goble, Carole, Li, Peter, Borkum, Mark, Bechhofer, Sean   +10 more
core  

BACCardI - a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison [PDF]

, 2005
Bartels D, Kespohl S, Albaum S, et al. BACCardI - a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison. Bioinformatics.
Kespohl, Sebastian, Drüke, Tanja, Albaum, Stefan ; https://orcid.org/, Bartels, Daniela, Kaiser, Olaf, Goesmann, Alexander ; https://orcid.org/, Pühler, Alfred ; https://orcid.org/, Schuster, Stephan C., Raddatz, Günter, Stoye, Jens ; https://orcid.org/, Herold, Julia, Pfeiffer, Friedhelm, Meyer, Folker   +12 more
core   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data [PDF]

, 2013
<p>Motivation: Stable isotope-labelling experiments have recently gained increasing popularity in metabolomics studies, providing unique insights into the dynamics of metabolic fluxes, beyond the steady-state information gathered by routine mass ...
Achcar, Fiona,, Chokkathukalam, Achuthanunni, Creek, DJ, Barrett, M.P., Chokkathukalam, A., Breitling, Rainer, Creek, D.J., Breitling, R., Breitling, Rainer,, Achcar, Fiona, Achcar, F., Chokkathukalam, Achuthanunni,, Breitling, R, Jankevics, A, Jankevics, A., Jankevics, Andris, Creek, Darren J.,, Creek, Darren J., Achcar, F, Barrett, MP, Barrett, Michael P., Chokkathukalam, A, Jankevics, Andris,, Barrett, Michael P.,   +23 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Shape Analysis in Bioinformatics [PDF]

, 2009
In this thesis we explore two main themes, both of which involve proteins. The first area of research focuses on the analyses of proteins displayed as spots on 2-dimensional planes.
Petty, Emma Marie
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Bioinformatics Approach to Detect Chromosomal Variation [PDF]

, 2009
[[abstract]]Since there occurs an unavoidable rearrangement of the human DNA sequence during its transcription, such a rearrangement will influence the expression of the protein amino acid sequence, which becomes important information on genetic ...
ceng yu jie
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source