Results 131 to 140 of about 640,321 (318)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Bioinformatics tools for cellular communication analysis from single cell RNA sequencing data [PDF]

, 2023
reservedCell-cell interactions play a fundamental role in the coordination of all the cellular activities, and are thus pivotal for the physiopathology of the living organisms.
TUSSARDI, GAIA
core  

Symbolic Entropy of the Amplitude rather than the Instantaneous Frequency of EEG Varies in Dementia

Entropy, 2015
The dynamics of human electroencephalography (EEG) have been proved to be related to cognitive activities. This study separately assessed the two EEG components, amplitude and rhythm, aiming to capture their individual contributions to cognitive ...
Pei-Feng Lin, Jenho Tsao, Men-Tzung Lo, Chen Lin, Yi-Chung Chang   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

GeneFisher-P: variations of GeneFisher as processes in Bio-jETI [PDF]

, 2008
Lamprecht A-L, Margaria T, Steffen B, Sczyrba A, Hartmeier S, Giegerich R. GeneFisher-P: variations of GeneFisher as processes in Bio-jETI. BMC Bioinformatics.
Sczyrba, Alexander ; https://orcid.org/, Sven Hartmeier, Margaria, Tiziana, Anna-Lena Lamprecht, Tiziana Margaria, Alexander Sczyrba, Steffen, Bernhard, Lamprecht, Anna-Lena, Hartmeier, Sven, Bernhard Steffen, Robert Giegerich, Giegerich, Robert   +11 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
Kierzek, A.M., Eriko Takano (50986), Breitling, Rainer, Albert Gevorgyan, Gevorgyan, A., Breitling, R., Breitling, Rainer,, Andrzej M Kierzek, Zakrzewski, Piotr, Breitling Rainer, Gevorgyan Albert, Piotr Zakrzewski (111739), Piotr Zakrzewski, Rainer Breitling (4371), Eriko Takano, Medema, M.H., Takano, Eriko,, Zakrzewski Piotr, Gevorgyan, Albert, Takano Eriko, Kierzek, Andrzej M., Zakrzewski, P., Takano, E., Rainer Breitling, Medema Marnix H., Gevorgyan, Albert,, Marnix H. Medema (111741), Medema, Marnix H.,, Medema, Marnix H., Albert Gevorgyan (111745), Andrzej M. Kierzek (111748), Kierzek Andrzej M., Takano, Eriko, Zakrzewski, Piotr,, Marnix H Medema, Takano, Eriko; id_orcid, Kierzek, Andrzej M.,   +36 more
core   +1 more source

Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018

Microbiome, 2018
The Mid-Atlantic Microbiome Meet-up (M3) organization brings together academic, government, and industry groups to share ideas and develop best practices for microbiome research.
Jacquelyn S. Meisel, Daniel J. Nasko, Brian Brubach, Victoria Cepeda-Espinoza, Jessica Chopyk, Héctor Corrada-Bravo, Marcus Fedarko, Jay Ghurye, Kiran Javkar, Nathan D. Olson, Nidhi Shah, Sarah M. Allard, Adam L. Bazinet, Nicholas H. Bergman, Alexis Brown, J. Gregory Caporaso, Sean Conlan, Jocelyne DiRuggiero, Samuel P. Forry, Nur A. Hasan, Jason Kralj, Paul M. Luethy, Donald K. Milton, Brian D. Ondov, Sarah Preheim, Shashikala Ratnayake, Stephanie M. Rogers, M. J. Rosovitz, Eric G. Sakowski, Nils Oliver Schliebs, Daniel D. Sommer, Krista L. Ternus, Gherman Uritskiy, Sean X. Zhang, Mihai Pop, Todd J. Treangen   +35 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source