Results 111 to 120 of about 640,321 (318)
Bioinformatics for Genome Analysis [PDF]
, 2005 Nesbo, Boucher and Doolittle (2001) used phylogenetic trees of four taxa to assess whether euryarchaeal genes share a common history. They have suggested that of the 521 genes examined, each of the three possible tree topologies relating the four taxa was supported essentially equal numbers of times.
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Geoseq: a tool for dissecting deep-sequencing datasets [PDF]
, 2010 Gurtowski J, Cancio A, Shah H, et al. Geoseq: a tool for dissecting deep-sequencing datasets. BMC Bioinformatics. 2010;11(1): 506.Background Datasets generated on deep-sequencing platforms have been deposited in various public repositories such as the ...
Gurtowski, James +20 more
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Effect of salidroside on the immune function of BCG-infected macrophages
Shanghai Jiaotong Daxue xuebao. Yixue banObjective·To Investigate the effects of salidroside (SAL) on the immune response of macrophages infected with BCG.Methods·RAW264.7 mouse macrophages were infected with BCG, and the experiments were divided into blank control (BCG), salidroside (SAL+BCG),
NI Shuyi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Metabolomics Bioinformatics Analysis
, 2023 The basics of data processing are to convert the original data file into a representation to help easily access the characteristics of each observed ion. These characteristics include ion retention time and m/z time, as well as ion intensity measurements in each raw data file.
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Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data [PDF]
Circulation: Cardiovascular Genetics, 2008 Michael R. Barnes, ed 554 pages. England, UK: John Wiley & Sons; 2007. 2nd ed. $90.00. Paperback. ISBN 978-0-470-02620-5 This book, now in its second edition for more than a year, is positioned at the intersection of disciplines including genetics, bioinformatics (the melding of computer science and biology), biomedical research, and molecular ...
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Bioinformatics: making large-scale science happen [PDF]
, 2012 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166Bionformatics is a rapidly evolving research field dedicated to analyzing and managing biological data with computational resources.
Beltran i Agulló, Sergi
core
Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family [PDF]
, 2008 Wagner H, Morgenstern B, Dress A. Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family. Algorithms for Molecular Biology.
Andreas Dress +8 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source