Results 91 to 100 of about 22,135,367 (247)

Construction and Analysis of a ceRNA Network Reveals Potential Prognostic Markers in Colorectal Cancer

Frontiers in Genetics, 2020
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes.
Li Guo, Guowei Yang, Yihao Kang, Sunjing Li, Rui Duan, Lulu Shen, Wenwen Jiang, Bowen Qian, Zibo Yin, Tingming Liang, Tingming Liang   +10 more
doaj   +1 more source

Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis

Computational and Structural Biotechnology Journal, 2020
Synthetic lethality is thought to play an important role in anticancer therapies. Herein, to understand the potential distributions and relationships between synthetic lethal interactions between genes, especially for pairs deriving from different ...
Li Guo, Sunjing Li, Bowen Qian, Youquan Wang, Rui Duan, Wenwen Jiang, Yihao Kang, Yuyang Dou, Guowei Yang, Lulu Shen, Jun Wang, Tingming Liang   +11 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Lipidomics Bioinformatics Analysis

, 2023
Untargeted and targeted lipidomics are two categories of lipidomics that are often used in combination for the discovery and quantification of differential lipid molecules. Untargeted lipidomics uses LC-MS and GC-MS technologies to unbiasedly detect the dynamic changes of all lipid molecules before and after the stimulation or disturbance in cells ...
openaire   +2 more sources

Effect of salidroside on the immune function of BCG-infected macrophages

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To Investigate the effects of salidroside (SAL) on the immune response of macrophages infected with BCG.Methods·RAW264.7 mouse macrophages were infected with BCG, and the experiments were divided into blank control (BCG), salidroside (SAL+BCG),
NI Shuyi, JIANG Zhao, WANG Zhongtao, HE Shumei   +3 more
doaj   +1 more source

A quantitative account of genomic island acquisitions in prokaryotes [PDF]

, 2011
Background Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer.
van Passel, Mark W. J., van Passel Mark WJ, Passel, M.W.J., van, Mark WJ van Passel, Roos Tom E, Roos, T.E., van Passel, M.W.J., Roos, Tom E., Tom E Roos   +8 more
core   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Bioinformatic analysis v1

, 2019
Bioinformatics analysis The following analysis protocol describe Sequences processing and analysis section.
Rosangela Bevitori, Sanchari Sircar, Raquel Neves de Mello, Roberto Cotia Togawa, Tiago Silva Oliveira, Maria de Fátima Grossi de Sá, Nita Parekh   +6 more
openaire   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source