Results 91 to 100 of about 640,321 (318)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A bioinformatics analysis of the cell line nomenclature [PDF]

Bioinformatics, 2008
Abstract Motivation: Cell lines are used extensively in biomedical research, but the nomenclature describing cell lines has not been standardized. The problems are both linguistic and experimental. Many ambiguous cell line names appear in the published literature.
Sirarat Sarntivijai, Alexander S. Ade, Brian D. Athey, David J. States   +3 more
openaire   +2 more sources

A systems biology design and implementation of novel bioinformatics software tools for high throughput gene expression analysis [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Microarray technology has revolutionized the field of molecular biology by offering an efficient and cost effective platform for the simultaneous ...
Khan, Mohsin Amir Faiz
core  

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation

Stem Cells International, 2016
Current approaches in human embryonic stem cell (hESC) to pancreatic beta cell differentiation have largely been based on knowledge gained from developmental studies of the epithelial pancreas, while the potential roles of other supporting tissue ...
Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok   +8 more
doaj   +1 more source

Evaluating and Improving Automatic Sleep Spindle Detection by Using Multi-Objective Evolutionary Algorithms

Frontiers in Human Neuroscience, 2017
Sleep spindles are brief bursts of brain activity in the sigma frequency range (11–16 Hz) measured by electroencephalography (EEG) mostly during non-rapid eye movement (NREM) stage 2 sleep.
Min-Yin Liu, Adam Huang, Norden E. Huang, Norden E. Huang   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

EMMA 2-A MAGE-compliant system for the collaborative analysis and integration of microarray data [PDF]

, 2009
Dondrup M, Albaum S, Griebel T, et al. EMMA 2-A MAGE-compliant system for the collaborative analysis and integration of microarray data. BMC Bioinformatics.
Jünemann, Sebastian, Kahlke, Tim, Dondrup Michael, Christiane K Kleindt, Küster, Helge, Albaum, Stefan P, Goesmann, Alexander ; https://orcid.org/, Pühler Alfred, Heiko Neuweger, Runte Kai J, Mittard-Runte Virginie, Mertens, Dominik, Mittard-Runte, Virginie, Runte, Kaj J, Kuester, Helge, Henckel, Kolja, Linke Burkhard, Albaum, Stefan ; https://orcid.org/, Albaum, Stefan P., Tauch Andreas, Tim Kahlke, Goesmann Alexander, Pühler, Alfred ; https://orcid.org/, Goesmann, Alexander, Stefan P Albaum, Burkhard Linke, Kai J Runte, Helge Küster, Tauch, Andreas, Tille, Felix, Kleindt Christiane K, Virginie Mittard-Runte, Sebastian Jünemann, Küster Helge, Kolja Henckel, Griebel, Thasso, Kleindt, Christiane K., Kleindt, Christiane Katja, Griebel Thasso, Jünemann Sebastian, Neuweger Heiko, Alfred Pühler, Dondrup, Michael, Alexander Goesmann, Henckel Kolja, Kleindt, Christiane K, Andreas Tauch, Neuweger, Heiko, Linke, Burkhard, Dominik Mertens, Pühler, Alfred, Albaum Stefan P, Tille Felix, Kahlke Tim, Michael Dondrup, Thasso Griebel, Runte, Kai J., Felix Tille, Mertens Dominik   +58 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Bioinformatics Analysis of Estrogen-Responsive Genes [PDF]

, 2016
Estrogen is a steroid hormone that plays critical roles in a myriad of intracellular pathways. The expression of many genes is regulated through the steroid hormone receptors ESR1 and ESR2. These bind to DNA and modulate the expression of target genes.
openaire   +3 more sources