Results 81 to 90 of about 22,135,367 (247)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

University-level practical activities in bioinformatics benefit voluntary groups of pupils in the last 2 years of school [PDF]

, 2015
This work was supported in part by the Science and Technology Facilities Council under grant ST/M000435/1 to Daniel Barker.Background Bioinformatics—the use of computers in biology—is of major and increasing importance to biological sciences and medicine.
Rosanna G. Alderson, Gavin T. P. Muirhead, Comrie, Muriel H, Heleen Plaisier, Sweeney, Stuart D, Muirhead, Gavin T.P., James L. McDonagh, McDonagh, James L., Stuart D. Sweeney, Sweeney, Stuart D., Alderson, Rosanna G, Muriel M. Comrie, Leigh Duncan, Plaisier, Heleen, Duncan, Leigh, Barker, Daniel, Muirhead, Gavin TP, McDonagh, James L, Daniel Barker, Comrie, Muriel Margaret, Mcdonagh, James, Alderson, Rosanna Grace   +21 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Genome bioinformatic analysis of nonsynonymous SNPs [PDF]

BMC Bioinformatics, 2007
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP).
David F. Burke, Catherine L. Worth, Eva-Maria Priego, Tammy M. K. Cheng, Luc J. Smink, John A. Todd, Tom L. Blundell   +6 more
openaire   +4 more sources

The Generation Challenge Programme Platform: Semantic standards and workbench for crop science [PDF]

, 2008
The Generation Challenge programme (GCP) is a global crop research consortium directed toward crop improvement through the application of comparative biology and genetic resources characterization to plant breeding.
Peralta, Barry, Lee, Jennifer, Anacleto, Mylah, Yap, Jan Michael, van Hintum, T.J.L., Balaji, Jayashree, Manansala, Kevin, Marshall, David, Akintunde, Akinnola, Schiltz, Gary, Ruiz, M., Metz, Thomas, Valerio, Rowena, Kikuchi, Shoshi, Jaiswal, Pankaj, Ulat, Victor Jun, Hintum, T.J.L., van, Mendoza, Michael Jonathan, Wagner, James, Collins, Anthony, Martins, Natalia, Braak, Kyle, Ruiz, Manuel, Good, Benjamin, Bruskiewich, Richard, Jun Ulat, Victor, Morales, Jeffrey, Costa, Marcos, Skofic, Milko, Detras, Jeffrey, Shah, Trushar, Zhang, Yi, McLaren, Graham, Satoh, Kouji, Hazekamp, Tom, Bruskiewich, R., Simon, Reinhard, Alamban, Ryan, Farmer, Andrew, Gregorio, Sergio, Meintjes, Ayton, Davenport, G., Takeya, Masaru, Casstevens, Terry, Ritter, Sebastian, Barboza, Lord Hendrix, Rouard, M., Wanchana, Samart, Almodiel, Roque, Morris, Jane, Thongjuea, Supat, Pappas, Georgios, Senger, M., Wilkinson, Mark, Dereeper, Alexis, Rouard, Mathieu, Doi, Koji, Portugal, Arllet, Senger, Martin, Davenport, Guy, Mauleon, Ramil, Van Hintum, Theo, Mauleon, Ramil P., Rojas, Edwin, Hermocilla, Joseph, Echavez, Michael   +65 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bioinformatics Analysis of Estrogen-Responsive Genes [PDF]

, 2016
Estrogen is a steroid hormone that plays critical roles in a myriad of intracellular pathways. The expression of many genes is regulated through the steroid hormone receptors ESR1 and ESR2. These bind to DNA and modulate the expression of target genes.
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source