Results 81 to 90 of about 23,754,274 (255)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

University-level practical activities in bioinformatics benefit voluntary groups of pupils in the last 2 years of school [PDF]

, 2015
This work was supported in part by the Science and Technology Facilities Council under grant ST/M000435/1 to Daniel Barker.Background Bioinformatics—the use of computers in biology—is of major and increasing importance to biological sciences and medicine.
Rosanna G. Alderson, Gavin T. P. Muirhead, Comrie, Muriel H, Heleen Plaisier, Sweeney, Stuart D, Muirhead, Gavin T.P., James L. McDonagh, McDonagh, James L., Stuart D. Sweeney, Sweeney, Stuart D., Alderson, Rosanna G, Muriel M. Comrie, Leigh Duncan, Plaisier, Heleen, Duncan, Leigh, Barker, Daniel, Muirhead, Gavin TP, McDonagh, James L, Daniel Barker, Comrie, Muriel Margaret, Mcdonagh, James, Alderson, Rosanna Grace   +21 more
core   +1 more source

Construction and Analysis of a ceRNA Network Reveals Potential Prognostic Markers in Colorectal Cancer

Frontiers in Genetics, 2020
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes.
Li Guo, Guowei Yang, Yihao Kang, Sunjing Li, Rui Duan, Lulu Shen, Wenwen Jiang, Bowen Qian, Zibo Yin, Tingming Liang, Tingming Liang   +10 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Development of system for analysis and prediction of function for DNA sequences

, 2009
[[abstract]]After the completion of human genome project, Arabidopsis , rice and other species, genome researchers are shifting their research attentions from structural genomics to functional genomics.
Han-Wei Wu
core  

Effect of salidroside on the immune function of BCG-infected macrophages

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To Investigate the effects of salidroside (SAL) on the immune response of macrophages infected with BCG.Methods·RAW264.7 mouse macrophages were infected with BCG, and the experiments were divided into blank control (BCG), salidroside (SAL+BCG),
NI Shuyi, JIANG Zhao, WANG Zhongtao, HE Shumei   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Bioinformatics: making large-scale science happen [PDF]

, 2012
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166Bionformatics is a rapidly evolving research field dedicated to analyzing and managing biological data with computational resources.
Beltran i Agulló, Sergi
core   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source