Results 61 to 70 of about 1,076,718 (296)

Protective factors as biomarkers and targets for prevention and treatment of diabetic nephropathy: From current human evidence to future possibilities

Journal of Diabetes Investigation, 2020
Although hyperglycemia, high blood pressure and aging increase the risk of developing kidney complications, some diabetes patients exposed to these risk factors do not develop kidney disease, suggesting the presence of endogenous protective factors ...
Natalia Nowak
doaj   +1 more source

Hyb:A bioinformatics pipeline for the analysis of CLASH (crosslinking, ligation and sequencing of hybrids) data [PDF]

, 2013
Peer reviewedPublisher ...
Aiba, Aleksandra Helwak, Altschul, Anthony J. Travis, Aravin, Chi, Chi, David Tollervey, Dodt, Field, Filipowicz, Gong, Granneman, Grzegorz Kudla, Hafner, Hansen, Helwak, Jonathan Moody, Kent, Kim, Kudla, Langmead, Leung, Licatalosi, Lorenz, Markham, Memczak, Quinlan, Rost, Simpson, Ule, Wlotzka, Zhang   +32 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

RIBAP: a comprehensive bacterial core genome annotation pipeline for pangenome calculation beyond the species level

Genome Biology
Microbial pangenome analysis identifies present or absent genes in prokaryotic genomes. However, current tools are limited when analyzing species with higher sequence diversity or higher taxonomic orders such as genera or families.
Kevin Lamkiewicz, Lisa-Marie Barf, Konrad Sachse, Martin Hölzer   +3 more
doaj   +1 more source

Loss-of-Imprinting of HM13 Leads to Poor Prognosis in Clear Cell Renal Cell Carcinoma

Biomolecules
Genomic imprinting refers to the epigenetic silencing of one of both alleles in a parent-of-origin-specific manner, particularly in genes regulating growth and development.
Floris Voorthuijzen, Cedric Stroobandt, Wim Van Criekinge, Tine Goovaerts, Tim De Meyer   +4 more
doaj   +1 more source

Simulated single molecule microscopy with SMeagol

, 2016
SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation, and optimization of advanced analysis methods for live cell single molecule microscopy data ...
Boucharin, Alexis, Elf, Johan, Fange, David, Lindén, Martin, Ćurić, Vladimir   +4 more
core   +2 more sources

An Overview of the Use of Neural Networks for Data Mining Tasks [PDF]

, 2012
In the recent years the area of data mining has experienced a considerable demand for technologies that extract knowledge from large and complex data sources.
Alberts B, Alpaydin E, Ando T, Blake CL, Bramer MA, Castanheira LG, Han J, Lu H, Mitchell M, Ni X, Quinlan RJ, Rumelhart DE, Shafer JC, Shendure J, Simić D, Stahl F, Steinwart I, Surjandari I, Wei JS, Widrow B, Witten IH, Zaslavsky B, Zhang D   +22 more
core   +1 more source

Genome bioinformatic analysis of nonsynonymous SNPs [PDF]

BMC Bioinformatics, 2007
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP).
Burke, David, Worth, CL, Priego, EM, Cheng, T, Smink, LJ, Todd, John, Blundell, Tom   +6 more
openaire   +5 more sources

Bioinformatic analysis of WxL domain proteins

Saudi Journal of Biological Sciences, 2023
The WxL domain is found on the cell surface of many bacteria, most of which are commensal gut bacteria. Its functions are generally identified as being related to virulence and/or peptidoglycan attachment, but there is so far no clear function or structure for this domain.
Hassan, M.U., Williamson, M.P.
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source