Results 71 to 80 of about 640,321 (318)

Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus

Scientific Reports
Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes employing error-prone replicases. Thereby, they routinely generate a large ‘
Sandra Triebel, Kevin Lamkiewicz, Nancy Ontiveros, Blake Sweeney, Peter F. Stadler, Anton I. Petrov, Michael Niepmann, Manja Marz   +7 more
doaj   +1 more source

Structure and Hierarchy of Influenza Virus Models Revealed by Reaction Network Analysis

Viruses, 2019
Influenza A virus is recognized today as one of the most challenging viruses that threatens both human and animal health worldwide. Understanding the control mechanisms of influenza infection and dynamics is crucial and could result in effective future ...
Stephan Peter, Martin Hölzer, Kevin Lamkiewic, Pietro Speroni di Fenizio, Hassan Al Hwaeer, Manja Marz, Stefan Schuster, Peter Dittrich, Bashar Ibrahim   +8 more
doaj   +1 more source

Characterization of RNA content in individual phase-separated coacervate microdroplets

Nature Communications, 2022
Here, the authors demonstrate that single cell RNA sequencing technology can be leveraged to characterize RNA content of individual membrane-free condensates formed by liquid-liquid phase separation processes such as coacervation.
Damian Wollny, Benjamin Vernot, Jie Wang, Maria Hondele, Aram Safrastyan, Franziska Aron, Julia Micheel, Zhisong He, Anthony Hyman, Karsten Weis, J. Gray Camp, T.‐Y. Dora Tang, Barbara Treutlein   +12 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Preface to Introduction to Protein Structural Bioinformatics [PDF]

, 2018
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics.
Abeln, Sanne, Feenstra, K. Anton, Feenstra, K. Anton; id_orcid, Abeln, Sanne; id_orcid   +3 more
core   +1 more source

A quantitative account of genomic island acquisitions in prokaryotes [PDF]

, 2011
Background Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer.
van Passel, Mark W. J., van Passel Mark WJ, Passel, M.W.J., van, Mark WJ van Passel, Roos Tom E, Roos, T.E., van Passel, M.W.J., Roos, Tom E., Tom E Roos   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Bioinformatic analysis of allergens [PDF]

Clinical and Translational Allergy, 2011
The number of resources containing data on the sequence, structure, and evolution of allergenic proteins has increased significantly in the last several years. At the same time, informatics resources related to the functioning of the immune system continue to mature rapidly.
openaire   +2 more sources

Bioinformatic analysis of WxL domain proteins

Saudi Journal of Biological Sciences, 2023
The WxL domain is found on the cell surface of many bacteria, most of which are commensal gut bacteria. Its functions are generally identified as being related to virulence and/or peptidoglycan attachment, but there is so far no clear function or structure for this domain.
Hassan, M.U., Williamson, M.P.
openaire   +3 more sources

DesignGG: an R-package and web tool for the optimal design of genetical genomics experiments [PDF]

, 2009
BACKGROUND: High-dimensional biomolecular profiling of genetically different individuals in one or more environmental conditions is an increasingly popular strategy for exploring the functioning of complex biological systems.
Fu, Jingyuan; id_orcid, Swertz, Morris A.,, Jansen Ritsert C, Breitling, Rainer, Breitling, R., Jansen, R., Breitling, Rainer,, Li, Y., Vera, Gonzalo,, Swertz, Morris A., Breitling Rainer, Swertz Morris A, Vera Gonzalo, Swertz, M., Vera, G., Li, Yang,, Swertz, Morris A.; id_orcid, Fu, Jingyuan,, Fu, Jingyuan, Morris A Swertz, Jansen, Ritsert C.,, Jansen, Ritsert C., Vera, Gonzalo, Rainer Breitling, Gonzalo Vera, Ritsert C Jansen, Jingyuan Fu, Yang Li, Fu Jingyuan, Li Yang, Fu, J.Y., Vera Rodríguez, Gonzalo, Li, Yang   +32 more
core   +1 more source