Results 101 to 110 of about 22,135,367 (247)

Bioinformatics for Genome Analysis [PDF]

, 2005
Nesbo, Boucher and Doolittle (2001) used phylogenetic trees of four taxa to assess whether euryarchaeal genes share a common history. They have suggested that of the 521 genes examined, each of the three possible tree topologies relating the four taxa was supported essentially equal numbers of times.
openaire   +2 more sources

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data [PDF]

Circulation: Cardiovascular Genetics, 2008
Michael R. Barnes, ed 554 pages. England, UK: John Wiley & Sons; 2007. 2nd ed. $90.00. Paperback. ISBN 978-0-470-02620-5 This book, now in its second edition for more than a year, is positioned at the intersection of disciplines including genetics, bioinformatics (the melding of computer science and biology), biomedical research, and molecular ...
openaire   +1 more source

Characterization of the human patatin-like phospholipase familys⃞

Journal of Lipid Research, 2006
Several publications have described biological roles for human patatin-like phospholipases (PNPLAs) in the regulation of adipocyte differentiation. Here, we report on the characterization and expression profiling of 10 human PNPLAs.
Paul A. Wilson, Scott D. Gardner, Natalie M. Lambie, Stephane A. Commans, Daniel J. Crowther   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

DesignGG: an R-package and web tool for the optimal design of genetical genomics experiments [PDF]

, 2009
BACKGROUND: High-dimensional biomolecular profiling of genetically different individuals in one or more environmental conditions is an increasingly popular strategy for exploring the functioning of complex biological systems.
Fu, Jingyuan; id_orcid, Swertz, Morris A.,, Jansen Ritsert C, Breitling, Rainer, Breitling, R., Jansen, R., Breitling, Rainer,, Li, Y., Vera, Gonzalo,, Swertz, Morris A., Breitling Rainer, Swertz Morris A, Vera Gonzalo, Swertz, M., Vera, G., Li, Yang,, Swertz, Morris A.; id_orcid, Fu, Jingyuan,, Fu, Jingyuan, Morris A Swertz, Jansen, Ritsert C.,, Jansen, Ritsert C., Vera, Gonzalo, Rainer Breitling, Gonzalo Vera, Ritsert C Jansen, Jingyuan Fu, Yang Li, Fu Jingyuan, Li Yang, Fu, J.Y., Vera Rodríguez, Gonzalo, Li, Yang   +32 more
core   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

Nature Communications, 2018
Cytokinin fulfills its diverse roles in planta through a series of transcriptional responses. We identify the in vivo DNA binding site profiles for three genetically redundant type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs): ARR1, ARR10, and ARR12.
Mingtang Xie, Hongyu Chen, Ling Huang, Ryan C. O’Neil, Maxim N. Shokhirev, Joseph R. Ecker   +5 more
doaj   +1 more source

Bioinformatics

, 2019
Our bioinformatic staff consist of PhD-level scientists trained in computer languages, statistics, bioinformatics, genetics, and genomics. The software infrastructure for analysis is a combination of custom-built and open-source software.
Grace Melly (5914202)
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Author Correction: A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

Nature Communications, 2018
The original version of this Article contained an error in Fig. 3. Panel b was inadvertently duplicated and the correct panel c was originally omitted. This error has been corrected in both the PDF and HTML versions of the Article.
Mingtang Xie, Hongyu Chen, Ling Huang, Ryan C. O’Neil, Maxim N. Shokhirev, Joseph R. Ecker   +5 more
doaj   +1 more source