Results 101 to 110 of about 5,774 (236)

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

A composite bioink derived from lacrimal gland extracellular matrix and alginate

Journal of Applied Biomaterials & Functional Materials
With the high global prevalence of dry eye disease and around 17% attributed to aqueous deficient dry eye (ADDE), there is an urgent need for therapies targeting lacrimal gland (LG) insufficiency.
Luis Kasimir Leo, Katharina Elisabeth Wiebe-Ben Zakour, Julia Matros, Michael Christian Hacker, Florian Kai Groeber-Becker, Gerd Geerling, Joana Witt   +6 more
doaj   +1 more source

Preparation of tunable stiffness bioink

Journal of Physics: Conference Series
Abstract This study provides an experimental and theoretical basis for the precise design of bioink stiffness and is expected to promote the application of 3D bioprinting in complex tissue repair. We tackled key material challenges in 3D bioprinting by designing a tunable-stiffness bioink for complex tissue engineering.
Jiaqi Pang, Xujia Hao, Tianxing Gong
openaire   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Optimization of Gelatin and Crosslinker Concentrations in a Gelatin/Alginate-Based Bioink with Potential Applications in a Simplified Skin Model

Molecules
Three-dimensional bioprinting allows for the fabrication of structures mimicking tissue architecture. This study aimed to develop a gelatin-based bioink for a bioprinted simplified skin model. The bioink printability and chemical-physical properties were
Aida Cavallo, Giorgia Radaelli, Tamer Al Kayal, Angelica Mero, Andrea Mezzetta, Lorenzo Guazzelli, Giorgio Soldani, Paola Losi   +7 more
doaj   +1 more source

Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair

Advanced Science, EarlyView.
This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu, Nhu An Phan, Sy Trung Ngo, Minh Tri Phan, Thanh‐An Truong, Chi Cong Nguyen, Phuoc Thien Phan, Hoang‐Phuong Phan, Thanh Nho Do, Mai Thanh Thai   +9 more
wiley   +1 more source

Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro‐Vascularized Bone Regeneration

Advanced Science, EarlyView.
This study develops neural bioprinted piezoelectric scaffolds which construct local “sensor‐effector” circuit, inspired by the skeletal interoception system. Upon US stimulation sensing and mechanoelectrical coupling by PLLA nanofibers, the incorporated DRG neurons effect through Ca2+ influx‐induced enhanced secretion and expression of CGRP.
Yingze Su, Haomin Wang, Weixi Liu, Kangming Chen, Yiyang Min, Jinbo Zhu, Xueyang Li, Anning Su, Hao Yang, Lei Yang, Yun Ji, Yuxin Zhang, Jisi Zheng, Chi Yang, Chuanglong He, Tao Li, Shuo Chen, Tao Wu, Xiaodong Chen   +18 more
wiley   +1 more source

Enhanced bone regeneration with bioprinted GelMA/Bentonite scaffolds inspired by bone matrix

Virtual and Physical Prototyping
In bone tissue engineering, the search for improved repair methods is crucial, given the drawbacks of traditional strategies like donor site issues and immune rejection.
Jian Wang, Dongyang Zhou, Guangchao Wang, Miaomiao Wang, Fuxiao Wang, Yafei Han, Xiao Chen, Yan Hu, Fengjin Zhou, Zhongmin Shi, Xiaoxiang Ren, Jiacan Su   +11 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source